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Chronic Myeloid Leukemia

Catalog No Product Description CAS No. Purity Structural Formula
BP3883
Indole-3-acetic acid
Indole-3-acetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group. It has a role as an auxin, a plant hormone, a mouse metabolite, a plant metabolite and a human metabolite. It is a member of indole-3-acetic acids and a monocarboxylic acid. It is a conjugate acid of an indole-3-acetate. Indole-3-acetic acid , a well-known phytohormone, can also be a signaling molecule in bacteria and therefore can have a direct effect on bacterial physiology.
87-51-4 98% Indole-3-acetic acid
BP3110
Deguelin
Deguelin, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin is a potent in vitro inhibitor of the mutant form of NPM1, which provides the molecular basis for its anti-leukemia activities in NPM1 mutant acute myeloid leukemia cells.Deguelin has anti-cancer activity, such as anti osteosarcoma, lung cancer; via inducing the apoptosis of cancer cells through a ROS driven Akt pathway, EPC suppression by FAK-integrin-ILK-dependent actin remodeling .Deguelin possesses antitumor effect by targeting Akt in dual axis such as EGFR and IGF1R signaling pathways and suggests that it provides an applicable therapeutic strategy for HNSCC patients. Deguelin is a rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.
522-17-8 98% Deguelin
BP0759
Icaritin
Icaritin, a potent inhibitor of transcription factor SREBPs, which exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, hormone regulation, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.
118525-40-9 98% Icaritin
BP5489 77704-34-8 98% Cucurbitacin IIa 2-O-glucoside
BP5619 31519-22-9 1,4-Dihydroxy-2-naphthoic acid
BP0703 26833-85-2 Harringtonine
BP5234
Momilacton A
Momilactone A is a pimarane diterpenoid and a diterpene lactone.
51415-07-7 98% Momilacton A
BP0408
Crotonoside
Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine.
1818-71-9 98% Crotonoside
BP0831
Kirenol
Kirenol possesses anti-bacteria, immunosuppression, anti-obesity, anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. Kirenol has significant potential for its discovery as a new lead compound for management of topical pain and inflammation; it can upregulate nuclear Annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats. Kirenol can attenuate experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. Kirenol activates the BMP and Wnt/β-catenin signaling pathways.
52659-56-0 98% Kirenol
SBP00765 53319-52-1 Isogosferol
BP5254
24-epi-Brassinolide
24-epi-brassinolide is a brassinosteroid, a 3alpha-hydroxy steroid, a 2alpha-hydroxy steroid, a 22-hydroxy steroid and a 23-hydroxy steroid.
78821-43-9 97% 24-epi-Brassinolide
SBP01392 24274-60-0 Acetylcephalotaxine
SBP03874
Indigo
Indigo and indirubin are potent aryl hydrocarbon receptor ligands present in human urine, the endogenous levels and potencies of indirubin and indigo are such that they activate aryl hydrocarbon receptor (AhR) -mediated signaling mechanisms in vivo . Indigo participates in isolating oxygenase genes, indigo carmine angiography provides visual information on foot perfusion, using indigo dye and synergistic halide additives can inhibit mild steel corrosion in sulphuric acid.
482-89-3 98% Indigo
SBP01445 84567-08-8 4-Hydroxycephalotaxine
SBP03522 51020-45-2 Demethylcephalotaxinone
BP5284 13114-27-7 98% Zeatin
SBP00083 1187925-30-9 Carabrolactone A
BP4982
28-Homobrassinolide
28-Homobrassinolide is a brassinosteroid.
82373-95-3 98% 28-Homobrassinolide