Tubeimoside I shows potent antitumor and antitumor-promoting effects, it is an efficient apoptosis-inducing agent for choriocarcinoma cells, which exerts its effects, at least partially, by the induction of mitochondrial dysfunction and regulation of the p38/MAPK, ERK1/2 and PI3K/Akt signaling pathways. It also shows potent anti-microtubule activity, it can inhibit binding of known tubulin ligands.

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway, it inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells, it induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway. Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol also shows α-glucosidase inhibitory activity.