Eupatoriochromene retard seed germination , reduced radicle and hypocotyl growth of weed and crop plant seedlings and increased adventitious root formation of mung bean cuttings. Eupatoriochromene has insecticidal activity, it exhibits toxicity againstCulex pipiens (house mosquito) larvae andOncopeltus fasciatus (large milkweed bug) nymphs.

Isoasatone A is a natural product from Heterotropa takaoi M.

Arenobufagin is a steroid lactone. It is functionally related to a bufanolide. Arenobufagin is a potent Na + /K + pump inhibitor, and is also a specific inhibitor of VEGF-mediated angiogenesis. Arenobufagin has antineoplastic effect that involves cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway. Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human liver cancer cells by inhibiting the PI3K/Akt/mTOR pathway. Arenobufagin exhibits potent anti-tumor activity against hepatocellular carcinoma HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF mediated angiogenesis by suppressing the VEGFR-2 signaling pathway.