Ingenol mebutate is a tetracyclic diterpenoid ester obtained by formal condensation of the carboxy group of (2Z)-2-methylbut-2-enoic (angelic) acid with the 3-hydroxy group of ingenol. Used for the topical treatment of actinic keratosis. It has a role as an antineoplastic agent. It is a carboxylic ester, a cyclic terpene ketone and a tetracyclic diterpenoid. It is functionally related to an angelic acid and an ingenol. Ingenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines, formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV. Ingenol mebutate is an effective treatment for actinic keratosis.

Acitretin has immunomodulatory effect, and low dose acitretin therapy is safe, well tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients, it for chemoprevention of non-melanoma skin cancers in renal transplant recipients. Acitretin dramatically improves the results of UV-B treatment in patients with severe psoriasis and it markedly decreases the effective cumulative UV-B dose. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva. Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection. All-trans-acitretin is a retinoid, an acitretin and an alpha,beta-unsaturated monocarboxylic acid. It has a role as a keratolytic drug.