Periplogenin plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.

Goitrin is a potent antithyroid compound, it is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase,leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine. Goitrin is responsible for the induction of glutathione S-transferases. (S)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has S-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent, an antithyroid drug and a plant metabolite. It is an enantiomer of a (R)-goitrin.

Silychristin is a flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase. It has a role as a metabolite, a lipoxygenase inhibitor, a radical scavenger and a prostaglandin antagonist. It is a secondary alpha-hydroxy ketone, a polyphenol, an aromatic ether, a member of 1-benzofurans and a flavonolignan. Silychristin is a plant growth regulator, is an anti-hepatotoxic agent, is also an inhibitor of horseradish peroxidases and lipoxygenase.

Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.