8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. It also exhibits time-and dose-dependent liver injury in mice. 8-Epidiosbulbin E acetate is an organic heterotricyclic compound and an organooxygen compound.

Zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. Zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells; it suppresses enterotoxigenic bacteroides fragilis infection-induced colonic inflammation through inhibition of NF-κΒ. Zerumbone exhibits a hepatoprotective effect against ALI through its antioxidant and anti-inflammatory activities and the possible mechanism might be mediated by the TLR4/NF-κB/COX-2 pathway. Zerumbone can be a potential candidate for development of immunosuppressive agent. Zerumbone is a sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia. It has a role as a glioma-associated oncogene inhibitor, an anti-inflammatory agent and a plant metabolite. It is a sesquiterpenoid and a cyclic ketone. It derives from a hydride of an alpha-humulene.