Sclareolide demonstrates a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.

Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability.

Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties.

Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively. Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent.

N-Methylflindersine shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM. N-Methylflindersine is an organic heterotricyclic compound, an organonitrogen heterocyclic compound and an oxacycle.

Isolinderalactone shows anti-inflammatory and anticancer capacity, it induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c, may become a novel treatment for triple-negative breast cancer in the future; it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM. Isolinderalactone is a member of benzofurans. It has a role as a metabolite.

Valeranone shows antileishmanial and cytotoxic activity.

Flavokawain A is an apoptotic inducer and immune- modulator ,it also shows anti-inflammatory, and anti-tumor activities.Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.Flavokawain A may suppress LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK.

Deoxycholic acid is a strong promoter of hepatocarcinogenesis with possible complete carcinogenicity in the liver and promotion potential for tumor development in the small intestine. Loss of deoxycholic acid-induced EGFR/Ras/MAPK pathway function potentiates deoxycholic acid-stimulated FAS-induced hepatocyte cell death via a reduction in the expression of c-FLIP isoforms. Deoxycholic acid is a bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively. It has a role as a human blood serum metabolite. It is a C24-steroid, a dihydroxy-5beta-cholanic acid and a bile acid. It is a conjugate acid of a deoxycholate.

N(5)-ethyl-L-glutamine is a N5-alkylglutamine where the alkyl group is ethyl. It has been isolated from green tea. It has a role as a geroprotector, a neuroprotective agent and a plant metabolite. It is a tautomer of a N(5)-ethyl-L-glutamine zwitterion.

Chenodeoxycholic acid is a dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. It has a role as a mouse metabolite and a human metabolite. It is a C24-steroid, a dihydroxy-5beta-cholanic acid and a bile acid. It is a conjugate acid of a chenodeoxycholate. Chenodeoxycholic acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. Chenodeoxycholic acid could reverse obesity in cHF-fed mice, mainly in response to the reduction in food intake.

Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth inhibitory activity against larvae of Drosophila melanogaster.