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Myocardial Ischemia/Reperfusion Injury

Myocardial ischemia/reperfusion (I/R) injury refers to the damage that occurs to heart muscle tissue when blood flow is restored after a period of ischemia (lack of oxygen). While reperfusion is essential for salvaging ischemic myocardium, it paradoxically can exacerbate cellular damage through mechanisms involving oxidative stress, inflammation, calcium overload, and mitochondrial dysfunction, leading to cardiomyocyte death and impaired cardiac function. Understanding I/R injury is crucial for developing protective strategies in conditions like myocardial infarction and cardiac surgery.
Catalog No Product Description CAS No. Purity Structural Formula
BP0001
1,2,3,4,6-Pentagalloylglucose
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose is a galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions. It has a role as a geroprotector, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a galloyl beta-D-glucose and a gallate ester. It is a conjugate acid of a 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose(1-).
14937-32-7 98% 1,2,3,4,6-Pentagalloylglucose
BP0527
Eleutheroside E
Eleutheroside E is a glycoside and a lignan.
39432-56-9 98% Eleutheroside E
BP1640
Shanzhiside
Shanzhiside has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
29836-27-9 97% Shanzhiside
BP0662
Ginsenoside Re
Ginsenoside Re is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including anti-diabetic, vasorelaxant, antihyperlipidemic, anti-ischemic, angiogenic, antioxidant, and anti-inflammation actions. It also exhibits potent neuroprotective effects against neuroinflammation in a murine model of ALS. Re increases HCAEC outward current via SKCa channel activation; it also increases the proliferation of CD4+ T cells with decreases cell death, and enhances viability of CD4+T cells through the regulation of IFN-γ-dependent autophagy activity. Ginsenoside Re is a ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding alpha-L-rhamnopyranosyl-(12)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
52286-59-6 98% Ginsenoside Re
BP0657
Ginsenoside Rb1
Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, cardioprotective, anti-obesity, anti-inflammatory, and anti-oxidative actions. Ginsenoside Rb1 can up-regulate the expression of GLUTs in adipose tissue, in addition to activate insulin signalling pathway, and may effectively ameliorate the progression of asthma through Relegating Th1/Th2. It inhibited Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM, activated Akt, phosphorylating GSK-3β and inhibited mPTP opening. Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as an anti-inflammatory drug, a radical scavenger, a neuroprotective agent, an apoptosis inhibitor, an anti-obesity agent and a plant metabolite. It is a glycoside, a tetracyclic triterpenoid and a ginsenoside.
41753-43-9 98% Ginsenoside Rb1
BP0666
Ginsenoside Rg3
Ginsenoside Rg3 is the main component of Red ginseng, it inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively, it also inhibits Aβ levels, NF-κB activity, and COX-2 expression. Ginsenoside-Rg3 possesses an ability to inhibit the lung metastasis of tumor cells, and the mechanism of its antimetastatic effect is related to inhibition of the adhesion and invasion of tumor cells, and also to anti-angiogenesis activity. It is a novel drug, capable of inhibiting the early of scarring (HS) and later HS. (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
14197-60-5 98% Ginsenoside Rg3
BP2174
Crocin V
Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3. Beta-D-glucosyl crocetin is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxylic acid groups of crocetin with the anomeric hydroxy group of beta-D-glucopyranose. It is a beta-D-glucoside and a dicarboxylic acid monoester. It is functionally related to a beta-D-glucose and a crocetin. It is a conjugate acid of a beta-D-glucosyl crocetin(1-).
58050-17-2 98% Crocin V
BP0221
Aurantioobtusin
Aurantio-obtusin is a trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.
67979-25-3 98% Aurantioobtusin
BP1073
Peiminine
Peiminine has potent anti-inflammatory, anti-allergic, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. Peiminine can inhibit lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.
18059-10-4 98% Peiminine
BP0040
20(R)-Ginsenoside Rg3
20(R)-Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-R positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an antioxidant and a plant metabolite. It is a glycoside, a tetracyclic triterpenoid and a ginsenoside.
38243-03-7 98% 20(R)-Ginsenoside Rg3
BP3218
Jionoside B1
Jionoside B1 has immunosuppressive activity, it shows the hepato-protective activity in the H2O2 induced liver injury experiments.Jionoside B1 exhibits the obvious inhibition against aldose reductase.
120406-37-3 98% Jionoside B1
BP1630
Isoastragaloside II
Isoastragaloside II is a cucurbitacin and a glycoside.
86764-11-6 98% Isoastragaloside II
BP0043 948046-15-9 98% 20(R)-Notoginsenoside R2
BP0384 146501-37-3 Complanatoside A
BP4449
Luteolinidin chloride
Luteolinidin chloride is an anthocyanidin chloride that has luteolinidin as the cationic counterpart. It contains a luteolinidin. Luteolinidin chloride (100µM) can significantly blunt the effects of NAD on the cellular responses to GD.
1154-78-5 98% Luteolinidin chloride
BP3034
Higenamine
Higenamine (HG) is a well-known selective activator of beta2-adrenergic receptor (β2-AR) with a positive inotropic effect. HG exerts an antispasmodic effect on cold-induced vasoconstriction by regulating the PI3K/Akt, ROS/α2C-AR and PTK9 pathways independently of the AMPK/eNOS/NO axis, it reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. HG enhances the antitumor effects of cucurbitacin B in breast cancer by inhibiting the interaction of AKT and CDK2. It attenuated LPS-induced depression-like behavior by regulating BDNF-mediated ER stress and autophagy. (RS)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (RS)-norcoclaurinium.
5843-65-2 98% Higenamine
BP4410
Regaloside C
Regaloside C is anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H2O2-induced heart H9C2 cells.
117591-85-2 98% Regaloside C
BP4602 1394-48-5 98% Acehytisine
SBP04131 71222-06-5 Schizandriside
BP1708
Feretoside
Feretoside can increase the expression of heat shock factor 1 (HSF1) by a factor of 1.153 at 3 uM.
27530-67-2 98% Feretoside