Isoescin IB is a natural product from Aesculus hippocastanum L.

Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotective prostaglandins in gastric epithelium.

Forsythoside H is a nartural product from Forsythia suspense (Thunb.) Vahl.