6-Hydroxyflavone was previously reported to bind to type A γ-aminobutyric acid (GABAA) receptors benzodiazepine (BZ) site with moderate binding affinity, it as a promising drug candidate for the treatment of anxiety-like disorders. 6-Hydroxyflavone and 6-methoxyflavone with potent anti-inflammatory activity jin kidney mesangial cells provides a new flavone scaffold and direction to develop naturally derived products for potential nephritis prevention and treatment.