Stachydrine hydrochloride promotes the protein expression of IL-12 and IL-6, as well as the mRNA expression of T-bet and RORγt, while inhibiting the mRNA expression of GATA-3 and Foxp3; the Th1/Th2/Th17/Treg paradigm induced by Stachydrine hydrochloride contributed to the reduction in uterine bleeding in RU486-induced abortion mice.

Jionoside B1 has immunosuppressive activity, it shows the hepato-protective activity in the H2O2 induced liver injury experiments.Jionoside B1 exhibits the obvious inhibition against aldose reductase.

Rhein has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities, it has been proved effective in treatment of experimental diabetic nephropathy , one of the mechanism is the Inhibition of the hexosamine pathway. Rhein has protective effect on liver injury, the mechanisms possibly contribute to its action of antioxidant and anti-inflammatory activity, also associated with its effect of inhibiting TGF-β1 and suppressing the activation of hepatic stellate cells.