Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

Praeruptorin E is a cardiotonic agent with selective cardiac calcium channel agonistic effect, it can relax swine coronary artery and decrease contractility in guinea-pig left atria. Praeruptorin E may be useful in the therapy of lung injury, it can protect mice from hydrochloric acid (HCl)-induced lung injury by inhibiting polymorphonuclear leukocytes (PMNs) influx, IL-6 release and protein exudation.

(+)-Praeruptorin A exerts distinct relaxant effects on isolated rat aorta rings, which may be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase.