Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under active oxygen stress state. Schisandrone can significantly decrease phosphorylation levels of Tau protein at 396, 262 sites, and relieve neuronal injury, but the phosphorylation level does not reach a negative cell level; it can suppress the Aβ-induced oxidative stress and inflammatory reaction through influencing NF-κB signaling pathway, exerting its protective effect on Alzheimer disease.

Hibifolin can act as a potential inhibitor of ADA, it protects neurons against A beta-induced apoptosis and stimulates Akt activation, which would be useful in developing potential drugs or food supplements for treating AD. Hibifolin behaves as a dual inhibitor of PGE2 and leukotriene B4 (LTB4) formation in peritoneal exudates, thus it shows anti-inflammatory activity.