Acitretin has immunomodulatory effect, and low dose acitretin therapy is safe, well tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients, it for chemoprevention of non-melanoma skin cancers in renal transplant recipients. Acitretin dramatically improves the results of UV-B treatment in patients with severe psoriasis and it markedly decreases the effective cumulative UV-B dose. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva. Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection. All-trans-acitretin is a retinoid, an acitretin and an alpha,beta-unsaturated monocarboxylic acid. It has a role as a keratolytic drug.