7-Ethyl-10-Hydroxycamptothecin is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. 7-Ethyl-10-hydroxycamptothecin shows cytotoxicity against breast cancer, it efficiently target-bind to the colon and lungs of mice.

Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine.

7-ethylcamptothecin is a pyranoindolizinoquinoline. 7-Ethylcamptothecin has the superior antitumor activity than camptothecin, it has a stronger growth-inhibiting activity against tumor cells and remains in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethylcamptothecin is a derivative of camptothecin and a key intermediate in the synthesis of 7-ethyl-10-hydroxycamptothecin. 7-Ethylcamptothecin can be used in tumor related research.

10 methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, which has been proven to have high anti-cancer properties. By measuring the anti-tumor activity against the 2774 cell line, it was found that 10 Methoxycamptothecin has higher cytotoxicity than 10 Hydroxycamptothecin.

10-Hydroxycamptothecin is a pyranoindolizinoquinoline. 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.10-Hydroxycamptothecin anticancer, and antiangiogenic activities, it can prevent fibroblast proliferation and epidural scar adhesion after laminectomy in rats.