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KCNH2

KCNH2 (potassium voltage-gated channel subfamily H member 2) is a gene that encodes the alpha subunit of the human Ether-à-go-go-Related Gene (hERG) potassium channel, also known as Kv11.1. This voltage-gated potassium channel is critically involved in cardiac repolarization, specifically contributing to the rapid component of the delayed rectifier potassium current (IKr). Mutations in KCNH2 are a primary cause of congenital Long QT Syndrome type 2 (LQTS2), a disorder predisposing individuals to life-threatening ventricular arrhythmias.
Catalog No Product Description CAS No. Purity Structural Formula
BP0899
Luteoloside
Luteolin 7-O-beta-D-glucoside is a glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and a plant metabolite. It is a beta-D-glucoside, a trihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to a luteolin. It is a conjugate acid of a luteolin 7-O-beta-D-glucoside(1-).
5373-11-5 98% Luteoloside
BP1247
Salvianolic acid A
Salvianolic acid A has antioxidant, hepatoprotective, antithrombotic effect, and antiplatelet actions. it also has a significant protective effect against isoproterenol-induced myocardial infarction; it activates the Nrf2/HO-1 axis in RPE cells and protects against oxidative stress via activation of Akt/mTORC1 signaling. Salvianolic acid A (oral) can significantly improve glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats. It is a novel matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats.
96574-01-5 98% Salvianolic acid A
BP5725 1356494-03-5 98% 2'-O-Acetylthevetin A
BP1154
Protocatechualdehyde
3,4-dihydroxybenzaldehyde is a dihydroxybenzaldehyde.
139-85-5 98% Protocatechualdehyde
BP0464
Dehydroevodiamine
Dehydroevodiamine has anticholinesterase activity and an anti-amnesic effect, it also may be a novel and effective ligand for improvement of beta-amyloid type amnesia. Dehydroevodiamine has antiarrhythmic, and anti-inflammatory properties, the effect of dehydroevodiamine-mediated inhibition of the expression LPS-induced iNOS and COX-2 genes is due to under the suppression of NF-kappaB activation in the transcriptional level.
67909-49-3 99% Dehydroevodiamine
BP3002
Corypalmine
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
27313-86-6 98% Corypalmine
BP0059 60-38-8 3-Acetyl-Strophanthidin
BP3075 30219-16-0 98% Arenobufagin 3-hemisuberate
BP4193
Bufotalidin
Hellebrigenin is a steroid aldehyde, a steroid lactone, a 3beta-hydroxy steroid, a 14beta-hydroxy steroid, a 19-oxo steroid and a 5beta-hydroxy steroid. It has a role as an autophagy inducer, an antineoplastic agent, an apoptosis inducer, an antileishmanial agent, an animal metabolite and a plant metabolite. It is functionally related to a 5beta-bufanolide.
465-90-7 98% Bufotalidin
BP0002 116064-77-8 98% 1,2-Didehydromiltirone
BP1333 299-39-8 Sparteine sulfate
BP1008
Notoginsenoside Fc
Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
88122-52-5 98% Notoginsenoside Fc
SBP01570 60008-01-7 Oblongine
BP0717 630-64-8 Helveticoside
BP1176
Puerarin
Puerarin is a hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage. It has a role as an autophagy inducer, a ferroptosis inhibitor, an antioxidant, an antipyretic, an anti-inflammatory agent, a plant metabolite and a cardioprotective agent. It is a C-glycosyl compound and a hydroxyisoflavone. It is functionally related to an isoflavone. It is a conjugate acid of a puerarin(1-). Puerarin is a 5-HT2C receptor and benzodiazepine site antagonist, it exerts a regulatory effect on lipid accumulation by decreasing lipogenesis in hepatocytes, it may have therapeutic benefits in the treatment of fatty liver and lipid-related metabolic disorders, it also may act as an intracellular ROS scavenger, and its antioxidant properties may protect against Abeta25-35-induced cell injury,and apoptosis and could also promote the survival of PC12 cells.
3681-99-0 98% Puerarin
BP0245
Benzoylhypaconine
Benzoylhypaconine is a diterpene alkaloid with formula C31H43NO9 that is isolated from several Aconitum species. It has a role as a xenobiotic, a phytotoxin, a plant metabolite, a human urinary metabolite and a rat metabolite. It is a diterpene alkaloid, a tertiary alcohol, a triol, a secondary alcohol, a bridged compound, a benzoate ester, an organic heteropolycyclic compound, a polyether and a tertiary amino compound. It derives from a hydride of an aconitane.
63238-66-4 98% Benzoylhypaconine
SBP04382 84-39-9 Stylopine
BP0842 32854-75-4 98% Lappaconitine
BP4602 1394-48-5 98% Acehytisine
BP0337
Chasmanine
Chasmanine is a diterpene alkaloid with formula C25H41NO6 that is isolated from several Aconitum species. It has a role as an antifeedant and a plant metabolite. It is a diol, a diterpene alkaloid, a tertiary alcohol, a secondary alcohol, a bridged compound, an organic heteropolycyclic compound, a polyether and a tertiary amino compound. It derives from a hydride of an aconitane. Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecticidal activities against larvae of Bradysia odoriphaga Yan et Zhang.
5066-78-4 98% Chasmanine