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OPRK1

OPRK1 encodes the Kappa Opioid Receptor 1 (KOR1), a G protein-coupled receptor primarily involved in mediating the analgesic, sedative, and dysphoric effects of opioid compounds, particularly dynorphins. It plays a crucial role in pain modulation, stress responses, and addiction pathways. KOR1 activation can lead to hyperpolarization of neurons and inhibition of neurotransmitter release, contributing to its diverse physiological and pharmacological actions. Dysregulation of OPRK1 is implicated in various neurological and psychiatric conditions.
Catalog No Product Description CAS No. Purity Structural Formula
BP3721
Dehydrocorydaline nitrate
Dehydrocorydaline has anti-inflammatory activity, it has antinociceptive effects in mouse models of inflammatory pain, the effects involve the opioid receptor and inflammatory cytokines. Dehydrocorydaline can inhibit elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages.Dehydrocorydaline not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to dehydrocorydaline.
13005-09-9 98% Dehydrocorydaline nitrate
SBP00540
Suberosin
Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent. Suberosin inhibits PHA-induced PBMC proliferation, at least in part, through reduction of [Ca2+]i, ERK, NF-AT, and NF-kappaB activation, and early gene expression in PBMC including cyclins and cytokines, and arrest of cell cycle progression in the cells. Suberosin is a member of the class of coumarins in which the coumarin ring is substituted at positions 6 and 7 by a 3-methylbut-2-en-1-yl group and a methoxy group, respectively. A natural product found in Citropsis articulata. It has a role as an anticoagulant and a plant metabolite. It is a member of coumarins and an aromatic ether. It is functionally related to a 7-demethylsuberosin.
581-31-7 98% Suberosin
BP3675 26067-60-7 90% Dihydropalmatine
BP4259 82375-30-2 98% Humantenirine
BP3384
Tetrahydrocolumbamine
(S)-tetrahydrocolumbamine is a berberine alkaloid consisting of columbamine having four extra hydrogens at positions 5, 8, 13 and 13a and (S)-configuration. It is a berberine alkaloid and an organic heterotetracyclic compound. It is functionally related to a columbamine.
483-34-1 98% Tetrahydrocolumbamine
BP0245
Benzoylhypaconine
Benzoylhypaconine is a diterpene alkaloid with formula C31H43NO9 that is isolated from several Aconitum species. It has a role as a xenobiotic, a phytotoxin, a plant metabolite, a human urinary metabolite and a rat metabolite. It is a diterpene alkaloid, a tertiary alcohol, a triol, a secondary alcohol, a bridged compound, a benzoate ester, an organic heteropolycyclic compound, a polyether and a tertiary amino compound. It derives from a hydride of an aconitane.
63238-66-4 98% Benzoylhypaconine
BP0842 32854-75-4 98% Lappaconitine
SBP00054
Tetrahydroalstonine
Tetrahydroalstonine is a heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species. It has a role as a plant metabolite. It is a methyl ester, a yohimban alkaloid and an organic heteropentacyclic compound. It is a conjugate base of a tetrahydroalstonine(1+). Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively.
6474-90-4 98% Tetrahydroalstonine
SBP02170 482-68-8 Sarpagine
BPF8384
(-)-Corydalmine
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
30413-84-4 98% (-)-Corydalmine
BP2448 548-40-3 Oxyacanthine
BPF7283
Schinifoline
Schinifoline is a member of quinolines.
80554-58-1 98% Schinifoline
SBP02088 1422506-49-7 Rauvotetraphylline A
SBP00899 604-99-9 Tombozine
BPF8520
Protopine hydrochloride
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors.
6164-47-2 98% Protopine hydrochloride
SBP03110 639-36-1 Akuammidine
BPF9502 110011-77-3 98% 8-O-Ethylyunaconitine
BPC0170 501-33-7 8-Azabicyclo-3.2.1-octan-3-ol
BPF3280
Menthone
Menthone has anti-inflammary activity, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as nuclear factor kappaB (NF-kappaB) activity induced by LPS and other inflammatory agents. Menthone and menthol enhances the skin permeability by disordering the ordered organization of SC lipids and extracts part of SC lipids. P-menthan-3-one is a p-menthane monoterpenoid that is p-menthane substituted by an oxo group at position 3. It has a role as a volatile oil component and a plant metabolite.
10458-14-7 98% Menthone
BPF7173
Sempervirine
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
6882-99-1 98% Sempervirine