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CACNA1H

CACNA1H encodes the alpha-1H subunit of voltage-dependent T-type calcium channels (CaV3.2). These low-voltage-activated channels play crucial roles in neuronal excitability, cardiac pacemaking, and endocrine secretion. Mutations in CACNA1H are associated with various neurological disorders, including childhood absence epilepsy, autism spectrum disorder, and primary aldosteronism, as well as influencing pain perception and cardiovascular function. Its pharmacological modulation is a target for therapeutic intervention.
Catalog No Product Description CAS No. Purity Structural Formula
BP0239
Bavachin
Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively. It is a cholesterol acyltransferase inhibitor, may have therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Bavachin can stimulate the genetic expression of VEGF in PB,and directly help the fracture healing, and potentially protect cartilage from inflammation-mediated damage in joints of osteoarthritis patients through decreasing IL-1β-induced activation of IKK-IκBα-NF-κB signaling pathway. Bavachin has suppressive effects against pigmentation by melanin in the skin.
19879-32-4 98% Bavachin
BP4041
6-Prenylnaringenin
6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin. It exhibits both mixed and non-competitive inhibitory characteristics against tyrosinase, tyrosinase is the rate-limiting enzyme for the production of melanin and other pigments via the oxidation of l-tyrosine. 6-Prenylnaringenin has anti-cancer potential , dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. 6-Prenylnaringenin can inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced inflammation (1μg/ear) in mice, it also exhibits inhibitory effects on skin-tumor promotion in anin vivo two-stagemouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]- anthracene (DMBA) as initiator and with TPA as promoter. 6-prenylnaringenin is a trihydroxyflavanone having a structure of naringenin prenylated at C-6. It has a role as a T-type calcium channel blocker. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one and a trihydroxyflavanone. It is functionally related to a (S)-naringenin.
68236-13-5 98% 6-Prenylnaringenin
BP0245
Benzoylhypaconine
Benzoylhypaconine is a diterpene alkaloid with formula C31H43NO9 that is isolated from several Aconitum species. It has a role as a xenobiotic, a phytotoxin, a plant metabolite, a human urinary metabolite and a rat metabolite. It is a diterpene alkaloid, a tertiary alcohol, a triol, a secondary alcohol, a bridged compound, a benzoate ester, an organic heteropolycyclic compound, a polyether and a tertiary amino compound. It derives from a hydride of an aconitane.
63238-66-4 98% Benzoylhypaconine
BP4110
Hydroxyl-γ-isosanshool
N-(2-Hydroxyisobutyl)-2,4,8,10,12-tetradecapentaenamide is a fatty amide.
127514-62-9 98% Hydroxyl-γ-isosanshool
SBP00394 21040-64-2 Spiradine F
BP0763
Indaconitine
Indaconitine is a natural product from Aconitum hemsleyanum PRITZ.
4491-19-4 98% Indaconitine
BP0277
Bisabolol Oxide A
Bisabololoxide A induces apoptosis in rat thymocytes.
22567-36-8 98% Bisabolol Oxide A
BP0200
Asarone
asarone is the trans-isomer of asarone. It has a role as an anticonvulsant and a GABA modulator.
2883-98-9 98% Asarone
BP4318 38864-21-0 N,N',N''-Triacetylchitotriose
BP0453 30984-80-6 Dauricinoline
BP5187 101247-24-9 Aljesaconitine B