Aloin B is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9R diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of phenols, a cyclic ketone and a member of anthracenes. Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation. Aloin B (Isobalaloin) is an orally active SARS-CoV-2 papain like protease (PLpro) inhibitor with IC50 values of 16.08 (hydrolytic activity) and 17.51 (deubiquitinase activity) μ M. Aloin B can be broken down into aloe emodin 9-anthrone by the gut microbiota of rats to exert its laxative effect. Aloin B can inhibit TPA (HY-18739) - induced ear edema, elevated levels of putrescine, and tumor promoting effects in mouse skin. Aloin B can be used in the research of anti inflammation and inhibition of tumor promotion, novel coronavirus pneumonia (covid-19) and constipation.