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MAPK8

MAPK8, also known as JNK1 (c-Jun N-terminal kinase 1), is a serine/threonine protein kinase that plays a crucial role in cellular responses to various extracellular stimuli, including environmental stress, inflammatory cytokines, and growth factors. It is involved in regulating cell proliferation, differentiation, survival, and apoptosis, making it a significant target in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. MAPK8 phosphorylates transcription factors like c-Jun, activating gene expression.
Catalog No Product Description CAS No. Purity Structural Formula
BP0527
Eleutheroside E
Eleutheroside E is a glycoside and a lignan.
39432-56-9 98% Eleutheroside E
BPF0598
Trachelogenin
Trachelogenin has antiproliferative effect, the mechanism is related to affect the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner.
34209-69-3 98% Trachelogenin
BP1492
Pteryxin
(+)-Pteryxin has muscle-relaxant props, it also shows hepatoprotective and nitric oxide prodn. inhibitory activity.
13161-75-6 98% Pteryxin
BP5211
Clerosterol
Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis. Clerosterol is a steroid. It derives from a hydride of a stigmastane.
2364-23-0 Clerosterol
BP0401
Costunolide
Costunolide has antipyretic, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-fungal activities, it possesses normo-glycemic and hypolipidemic activity. Costunolide inhibits RANKL-induced osteoclast differentiation by suppressing RANKL-mediated c-Fos transcriptional activity; it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1; it also induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release,. Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as a metabolite, an antiinfective agent, an antiparasitic agent, an anthelminthic drug, an antineoplastic agent and an antiviral drug. It is a heterobicyclic compound and a germacranolide.
553-21-9 98% Costunolide
BP0912
Magnoflorine
Magnoflorine possesses high activity as α-glucosidase inhibitor in vitro and in vivo, has antidiabetic potential activity; it also has sedative and anxiolytic effects, probably mediated by a GABAergic mechanism of action. Magnoflorine has protective effects, mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance. (S)-magnoflorine is an aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. It has a role as a plant metabolite. It is an aporphine alkaloid and a quaternary ammonium ion. It is functionally related to a (S)-corytuberine.
2141-09-5 98% Magnoflorine
BP0708
Hederacoside C
Hederacoside C is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. Hederacoside C has antispasmodic activity. Hederacoside C is a potent competitive inhibitor for serine protease porcine pancreatic elastase, shows comparable IC 50 value is 40.6 uM; it also non-competitively inhibits hyaluronidase activity in a dose- dependent fashion, shows comparable IC 50 value is 280.4 uM. Kalopanaxsaponin B is a triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus. It has a role as an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid, a carboxylic ester and a triterpenoid saponin. It is functionally related to a hederagenin.
14216-03-6 98% Hederacoside C
BP0171
Angelicin
Angelicin is a furanocoumarin. Angelicin has anti-cancer, antiviral, and anti-inflammatory activities;it regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Angelicin is a powerful inducer of erythroid differentiation and -globin mRNA accumulation of human leukemia K562 cells, it is a potential therapeutic approach in hematological disorders, including -beta-thalassemia and sickle cell anemia. ngelicin is a type of furan coumarin NF - κ B and MAPK signaling inhibitor with anti-inflammatory, antiviral, and anti-tumor activities. Angelicin can inhibit the lysis and replication of gamma herpesvirus (such as MHV-68), act in the early stages of viral infection, and may inhibit RTA gene expression (IC50=28.95 μ M). Angelicin also alleviates inflammatory responses by inhibiting NF - κ B phosphorylation and nuclear translocation, as well as inhibiting p38 and JNK phosphorylation. Angelicin downregulates anti apoptotic proteins (such as Bcl-2, Bcl xL, and Mcl-1) and activates caspase-9 and caspase-3 to induce apoptosis in neuroblastoma cells.
523-50-2 98% Angelicin
BP5360 34770-39-3 98% Aureusidin-6-O-neohesperidin
BP2220
Sphingomyelin
N-hexadecanoylsphingosine-1-phosphocholine is a sphingomyelin 34:1 in which the N-acyl group and sphingoid base are specified as hexadecanoyl and sphingosine respectively. It has a role as a mouse metabolite. It is functionally related to a hexadecanoic acid.
6254-89-3 98% Sphingomyelin
BP0964
Mulberroside A
Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics. Mulberroside A has neuroprotective, analgesic, anti-inflammatory, antiapoptotic, uricosuric, nephroprotective, hypoglycemic, and antidiabetic effects.It also can protect mice against ethanol-induced hepatic damage. Cis-Mulberroside A is a glycoside and a stilbenoid.
102841-42-9 98% Mulberroside A
BP0394
Cornuside
Cornuside has immunomodulatory, and anti-inflammatory activities, it has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties. Cornuside can treat myocardial I/R and protect the liver from CCl₄-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses.
131189-57-6 98% Cornuside
SBP02254
Olivil monoacetate
Prostephanaberrine is a natural product from Valeriana officinalis.
1016974-78-9 98% Olivil monoacetate
BP1839 28342-31-6 98% 6-Ethoxysanguinarine
BP3302
Oxypeucedanin
Oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.Oxypeucedanin has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. Oxypeucedanin is a furanocoumarin that is 7H-furo[3,2-g][1]benzopyran-7-one substituted by a [(2S)-3,3-dimethyloxiran-2-yl]methoxy group at position 4. It has a role as a plant metabolite. It is a furanocoumarin, a lactone and an epoxide.
737-52-0 98% Oxypeucedanin
BP5376 53000-16-1 98% 3-Methoxy-2,4,6-tris(methoxymethoxy)acetophenone
SBP02203 91269-84-0 Melilotigenin B
BP5291 59632-76-7 98% Anisomelic acid
SBP03146 67214-05-5 2''-O-Coumaroyljuglanin
BP5009
3,5,7-Trimethoxyflavone
Galangin 3,5,7-trimethyl ether is a trimethoxyflavone that is the 3,5,7-trimethyl ether derivative of galangin. It has a role as a plant metabolite. It is functionally related to a galangin.
26964-29-4 98% 3,5,7-Trimethoxyflavone