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SLC1A3

SLC1A3, also known as EAAT3 or GLAST, encodes a high-affinity glutamate transporter protein primarily expressed in astrocytes of the central nervous system. This transporter plays a crucial role in maintaining low extracellular glutamate concentrations, thereby preventing excitotoxicity and regulating synaptic transmission. Dysregulation of SLC1A3 has been implicated in various neurological conditions, including epilepsy, stroke, and neurodegenerative diseases, making it a significant target for therapeutic research.
Catalog No Product Description CAS No. Purity Structural Formula
BP1395
Timosaponin AIII
Timosaponin A-III is a natural product found in Anemarrhena asphodeloides. It has a role as a metabolite.
41059-79-4 98% Timosaponin AIII
BP1362
Tanshinone IIA
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione is an abietane diterpenoid.
568-72-9 98% Tanshinone IIA
BP0001
1,2,3,4,6-Pentagalloylglucose
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose is a galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions. It has a role as a geroprotector, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a galloyl beta-D-glucose and a gallate ester. It is a conjugate acid of a 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose(1-).
14937-32-7 98% 1,2,3,4,6-Pentagalloylglucose
BP1471
Camelliaside B
Camelliaside B is a natural product from Camellia oleifera Abel. Camelliaside b is a glycoside and a member of flavonoids.
131573-90-5 98% Camelliaside B
BP1470
Camelliaside A
Camelliaside A is a natural product from Camellia oleifera Abel.
135095-52-2 98% Camelliaside A
BP0397
Corylifol A
Corylifol A is a naturally occurring potent inhibitor of hCE2 and UDP-glucuronosyltransferase 1A1 (UGT1A1); it could be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. Corylifol A has antiinflammatory activity, it shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uΜ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells.
775351-88-7 98% Corylifol A
BP0527
Eleutheroside E
Eleutheroside E is a glycoside and a lignan.
39432-56-9 98% Eleutheroside E
SBP02860
Moracin O
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 uM. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
123702-97-6 98% Moracin O
BP1271
Sclareolide
Sclareolide demonstrates a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.
564-20-5 98% Sclareolide
BP5286 2366153-27-5 98% 1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone
BP0307
Campesterol
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory effect, it inhibits several pro-inflammatory and matrix degradation mediators typically involved in osteoarthritis- induced cartilage degradation, also sometimes used to treat some specific prostate conditions. Campesterol is a 3beta-hydroxy-Delta(5)-steroid, a C28-steroid, a member of phytosterols and a 3beta-sterol. It has a role as a mouse metabolite. It derives from a hydride of a campestane.
474-62-4 98% Campesterol
BP0639
Geraniin
Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death.
60976-49-0 98% Geraniin
BP4974
alpha-Amyrin
Alpha-amyrin is a pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an ursane. Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory potent to feasibility for a promising liver curative drug.
638-95-9 98% alpha-Amyrin
BP1323
Solasonine
Solasonine displays leishmanicidal activity against promastigote forms of L. amazonensis. Solasonine is a steroid, an azaspiro compound and an oxaspiro compound.
19121-58-5 98% Solasonine
BP0554
Eriocitrin
Eriocitrin is a disaccharide derivative that consists of eriodictyol substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant. It is a member of 4'-hydroxyflavanones, a rutinoside, a trihydroxyflavanone, a member of 3'-hydroxyflavanones, a disaccharide derivative and a flavanone glycoside. It is functionally related to an eriodictyol. Eriocitrin is powerful antioxidative flavonoid, it can prevent oxidative damages caused by acute exercise-induced oxidative stress, it also has lipid-lowering effect in rats on a high-fat and high-cholesterol diet. Eriocitrin is a potent inhibitor of human carbonic anhydrase VA isozyme.
13463-28-0 98% Eriocitrin
BP0899
Luteoloside
Luteolin 7-O-beta-D-glucoside is a glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and a plant metabolite. It is a beta-D-glucoside, a trihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to a luteolin. It is a conjugate acid of a luteolin 7-O-beta-D-glucoside(1-).
5373-11-5 98% Luteoloside
BP1369
Tectorigenin
Tectorigenin has hepatoprotective, antifibrotic, anti-leukemia, antioxidant, and anti-inflammatory activities, it could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer. Tectorigenin is a methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 5, 7 and 4' respectively. It has a role as an anti-inflammatory agent and a plant metabolite. It is a methoxyisoflavone and a member of 7-hydroxyisoflavones. It is functionally related to an isoflavone.
548-77-6 98% Tectorigenin
BP1072
Peimine
Peimine has good anti-inflammatory effects in vivo, it inhibits the production of inflammatory cytokines induced by LPS through blocking MAPKs and NF-κB signaling pathways. It also has antitussive and sedative actions, the action being suspected to be central in nature.
23496-41-5 98% Peimine
BP1028
Oleuropein
Oleuropein is a secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). Oleuropein exhibits anti-ischemic, antioxidative, hypolipidemic, in vitro antimycoplasmal , anti-inflammatory, and anti-cancer effects., it also may be helpful in the prevention of diabetic complications associated with oxidative stress. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion, and reduces viremia in duck hepatitis B virus (DHBV)-infected ducks. Oleuropein reduces TLR and MAPK signaling.
32619-42-4 98% Oleuropein
BP0063 20243-59-8 98% 3'-hydroxygenkwanin