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SMAD3

Catalog No Product Description CAS No. Purity Structural Formula
BP0339
Chebulinic acid
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity; it also is a natural inhibitor of vascular endothelial growth factor-A mediated angiogenesis. Chebulinic acid has hypotensive, antioxidant, anti-HIV, and anti-ulcer activities. Chebulinic acid has inhibitory effect on erythroid differentiation likely through changing transcriptional activation of differentiation relative genes, it or other tannins might influence the efficiency of some anti-tumor drugs-induced differentiation or the hematopoiesis processes.
18942-26-2 98% Chebulinic acid
BP4974
alpha-Amyrin
Alpha-amyrin is a pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an ursane. Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory potent to feasibility for a promising liver curative drug.
638-95-9 98% alpha-Amyrin
BP5408 136172-60-6 98% 6'-O-Caffeoylarbutin
BP4900
Salvianolic acid E
Salvianolic acid E is a natural product from Salvia miltiorrhiza Bge.
142998-46-7 98% Salvianolic acid E
BP2319
Resveratrol 12-C-β-glucopyranoside
Resveratrol, a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, blood-sugar-lowering, antiaging, and anti-cancer properties. It has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM, kinases, sirtuins, c-IAP1, c-IAP2, livin and XIAP. Resveratrol regulates gene transcription via activation of the stimulus-regulated protein kinases Raf and ERK and the stimulus-responsive transcription factors TCF and Egr-1.
163527-00-2 98% Resveratrol 12-C-β-glucopyranoside
BP4186
Withaferin A
Withaferin A(WFA) has anti-inflammatory, anti-oxidant, immune modulatory, cardioactive, antithrombotic and central nervous system effects, it could act as an anti-fibrotic compound against fibroproliferative diseases, including, but not limited to, cardiac interstitial fibrosis. WFA is a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. WFA is a potent breast cancer anti-metastatic agent and the anti-metastatic activity of WFA is, at least in part, mediated through its effects on vimentin and vimentin ser56 phosphorylation; it induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells, it can be exploited as a potent therapeutic agent for the treatment and prevention of cervical cancer without deleterious effects. Withaferin A is a withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity. It has a role as an antineoplastic agent and an apoptosis inducer. It is an epoxy steroid, a primary alcohol, a delta-lactone, a secondary alcohol, a 27-hydroxy steroid, an ergostanoid, an enone, a 4-hydroxy steroid and a withanolide.
5119-48-2 98% Withaferin A
BPI007 255376-57-9 98% Iodixanol Impurity E
BP5447 68592-15-4 98% 4-O-Methyl honokiol
BP1316
Skimmin
Skimmin has anti-inflammatory, and anti-cancer activities, it can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis; it also can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway.
93-39-0 98% Skimmin
BP4923
Lyciumin B
Lyciumin B is a cyclic peptide.
125756-66-3 98% Lyciumin B
BP2026
Baicalin methyl ester
Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).
82475-03-4 95% Baicalin methyl ester
BP1339
Stachydrine hydrochloride
Stachydrine hydrochloride promotes the protein expression of IL-12 and IL-6, as well as the mRNA expression of T-bet and RORγt, while inhibiting the mRNA expression of GATA-3 and Foxp3; the Th1/Th2/Th17/Treg paradigm induced by Stachydrine hydrochloride contributed to the reduction in uterine bleeding in RU486-induced abortion mice.
4136-37-2 98% Stachydrine hydrochloride
BP1838
Poricoic acid A
Poricoic acid A is a secondary alcohol, a dicarboxylic acid and a tricyclic triterpenoid. It has a role as a fungal metabolite.
137551-38-3 98% Poricoic acid A
BP5613 97653-92-4 Lucidone A
SBP00640 52213-27-1 3-Epicorosolic acid
SBP01750
Specioside
Specioside has antioxidant, analgesic, anti-dyspeptic, astringent, liver stimulating and wound healing activities. It ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans.
72514-90-0 98% Specioside
BP5621 1487423-55-1 Floramanoside D
BP0957
Monocrotaline
Monocrotaline is a pyrrolizidine alkaloid.
315-22-0 98% Monocrotaline
BP2414 425408-42-0 98% Ethyl chlorogenate
BP0043 948046-15-9 98% 20(R)-Notoginsenoside R2