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LOX-1

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a major receptor for oxidized low-density lipoprotein (oxLDL). Expressed on endothelial cells, macrophages, and smooth muscle cells, LOX-1 plays a critical role in the pathogenesis of atherosclerosis, inflammation, and thrombosis. Its activation by oxLDL contributes to endothelial dysfunction, foam cell formation, and plaque instability, making it a significant therapeutic target in cardiovascular diseases.
Catalog No Product Description CAS No. Purity Structural Formula
BP0001
1,2,3,4,6-Pentagalloylglucose
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose is a galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions. It has a role as a geroprotector, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a galloyl beta-D-glucose and a gallate ester. It is a conjugate acid of a 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose(1-).
14937-32-7 98% 1,2,3,4,6-Pentagalloylglucose
BP0611
Gallocatechin gallate
(-)-gallocatechin gallate is a gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of ()-gallocatechin. A natural product found in found in green tea. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an antineoplastic agent, a plant metabolite and a human xenobiotic metabolite. It is a catechin, a polyphenol and a gallate ester. It is functionally related to a gallic acid and a (-)-gallocatechin. Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabetic effects by increasing sensitivity of insulin. Gallocatechin gallate can decrease osteoclastogenesis at 20 microM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations.
4233-96-9 98% Gallocatechin gallate
BP5722 162413-63-0 98% Macrostemonoside I
BP3975
Salviaflaside
Salviaflaside has antioxidant activity.
178895-25-5 98% Salviaflaside
BP4121
Crocin IV
Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3. Bis(beta-D-glucosyl) crocetin is a diester resulting from the formal condensation of each of the carboxylic acid groups of crocetin with an anomeric hydroxy group of beta-D-glucopyranose. It is a beta-D-glucoside and a diester. It is functionally related to a beta-D-glucose and a crocetin.
57710-64-2 98% Crocin IV
BP5329
δ-Tocopherol
Delta-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite and a food antioxidant. It is a tocopherol and a vitamin E.
119-13-1 98% δ-Tocopherol
BP1715
Tsugaric acid A
Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage.
174391-64-1 98% Tsugaric acid A
BP5416 3627-51-8 98% Monascorubramin
BP5342
Rhamnocitrin 3-O-β-D-glucoside
Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune. Rhamnocitrin possesses significant anticataract activity and acts most likely due to its antioxidant property, it shows a significant protection against cloudiness in lenses induced by hydrogen peroxide and hydrocortisone in a dose dependent manner.Rhamnocitrin and kaempferol can augment cellular antioxidant defense capacity, at least in part, through regulation of HO-1 expression and MAPK signal transduction; they not only protect low-density lipoprotein from oxidation but also prevent atherogenesis through suppressing macrophage uptake of oxidized low-density lipoprotein.
41545-37-3 98% Rhamnocitrin 3-O-β-D-glucoside
SBP01907 159623-48-0 3,4-Secotirucalla-4(28),7,24-triene-3,26-dioic acid
BP5288
Eleutherin
Eleutherin is a member of p-quinones and a benzoisochromanequinone.
478-36-4 98% Eleutherin
SBP00229 107783-45-9 Coccinic acid
BP4913
6-Hydroxykaempferol 3-β-rutinoside
5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside is a glycosyloxyflavone that is 3,5,6,7,4'-pentahydroxyflavonol substituted by a rutinosyl group at position 3 via a glycosidic linkage. Isolated from Daphniphyllum calycinum, it exhibits antioxidant activity. It has a role as a metabolite and a radical scavenger. It is a rutinoside, a tetrahydroxyflavone, a glycosyloxyflavone and a disaccharide derivative. 6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
205527-00-0 98% 6-Hydroxykaempferol 3-β-rutinoside
SBP01374 140447-22-9 Ergosterol peroxide glucoside
BP5217
Ostruthine
Ostruthin is a terpene lactone. It has a role as a metabolite.
148-83-4 98% Ostruthine
BP3949 928340-97-0 Resveratrol-4'-O-(6"-galloyl)-β-D-glucopyranoside
SBP01387 58-95-7 α-Tocopherol acetate
SBP02297
8-Prenyldaidzein
8-prenyldaidzein is a 7-hydroxyisoflavone that is daidzein in which the aromatic hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite. It is a polyphenol, a member of 7-hydroxyisoflavones and an olefinic compound. It is functionally related to a daidzein. 8-Prenyldaidzein has cytotoxic properties against P-388 cells, its IC 50 values 5.82 ug/mL, it also exhibits very high antioxidant activity against DPPH radical scavenging.
135384-00-8 98% 8-Prenyldaidzein
BP4770
Cyclocurcumin
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It may have a therapeutic potential as a novel antivasoconstrictive natural product. Cyclocurcumin offers higher neuronal protection than curcumin, they both reduced the level of ROS caused by MPP+ treatment.
153127-42-5 98% Cyclocurcumin
BP4976 77636-08-9 98% Toddanone