7-Ethyl-10-Hydroxycamptothecin is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. 7-Ethyl-10-hydroxycamptothecin shows cytotoxicity against breast cancer, it efficiently target-bind to the colon and lungs of mice.

Apigenin-7-0-glucuronide is a glucosiduronic acid and a member of flavonoids.

Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride. Topotecan hydrochloride is a pyranoindolizinoquinoline. It has a role as an antineoplastic agent and an EC 5.99.1.2 (DNA topoisomerase) inhibitor. It contains a topotecan.

5-O-Demethylnobiletin is an ether and a member of flavonoids. 5-0-Demethylnobiletin has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. 5-O-Demethylnobiletin is a multi methoxyflavone isolated from Citrus jambhiri Lush. It is a direct inhibitor of 5-LOX (IC50=0.1 μ M) and does not affect the expression of COX-2. 5-O-Demethylnobiletin has anti-inflammatory activity, inhibiting the formation of leukotriene B (4) (LTB4) in rat neutrophils and the release of elastase in human neutrophils, with an IC50 value of 0.35 μ M

Alpinetin is an ether and a member of flavonoids. Alpinetin has antibacterial, anti-inflammatory, and anti-cancer activities; it inhibits proliferation ,regulates of the Bcl-2 family and XIAP expression, releases of cytochrome c and activates caspases. Alpinein is a flavonoid compound isolated from cardamom, which has anti-tumor, anti-inflammatory, liver protective, cardiovascular protective, lung protective, antibacterial, antiviral, and neuroprotective properties. Alpinetin can inhibit inflammation caused by lipopolysaccharide (LPS), activate PPAR - γ, activate Nrf2, and inhibit the expression of TLR4 to protect against LPS induced kidney injury.

Tenacissoside G is a natural product from Marsdenia tenacissima.

Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor.

Bavachalcone has antibiotic or anticancer activities, it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increasing AMPK activity and MnSOD expression and reducing mitochondrial oxidative stress.

3,6,7-Trimethylquercetagetin is a trimethoxyflavone that is the 3,6,7-trimethyl ether derivative of quercetagetin. It has a role as a metabolite and an antineoplastic agent. It is a trihydroxyflavone and a trimethoxyflavone. It is functionally related to a quercetagetin.

Tectochrysin is a monohydroxyflavone that is flavone substituted by a hydroxy group at position 4 and a methoxy group at position 7 respectively. It has a role as an antineoplastic agent, an antidiarrhoeal drug and a plant metabolite. It is a monomethoxyflavone and a monohydroxyflavone. It is functionally related to a flavone.

In a discrete O-methyltransferase mediated reaction, 8-Hydroxybergapten is O-methylated to penicillin by cell-free extracts of Ruta cells. 8-Hydroxybergapten has excellent anti wrinkle effects.

Euphorbiasteroid has anti-obesity activities, it inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells; it induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner.

Bellidifolin has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway. Bellidifolin shows interesting inhibitory activity of monoamine oxidases (MAO) A, it could be useful for treating type-2 diabetes, likely via the improvement of insulin resistance (IR). Bellidifolin also shows an antifungal effect (MIC values of 50 microg/mL). Bellidifolin is a member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris. It has a role as a metabolite, a hypoglycemic agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a polyphenol and a member of xanthones. It is functionally related to a bellidin.

Glabridin is a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory, which has antioxidative,anti-inflammatory, antimalarial, estrogen receptor agonism, anti-metastasis, anti-melanogenesis and neuroprotective effects. Glabridin may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

Bellidin is a member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris. It has a role as an antioxidant, a metabolite, a mutagen, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a radical scavenger. It is a tetrol and a member of xanthones. It is functionally related to a xanthone.