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Product name: Homoeriodictyol
Synonym name: Eriodictyol 3'-methyl ether; Eriodictyonone; Hersperetin
Catalogue No.: BP4836
Cas No.: 446-71-9
Formula: C16H14O6
Mol Weight: 302.282
Botanical Source:
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
HPLC of Homoeriodictyol
HNMR of Homoeriodictyol
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
96.2200
2.1918
1.9117
.3047
4.0927
5.2456
Low
87.5056
2.8899
No
No
Yes
No
Yes
No
0.6
Yes
No
Yes
No
Homoeriodictyol (CAS No.: 446-71-9) is a natural flavanoid compound widely found in various traditional herbaceous plants, especially known for its bitter masking activity. In recent years, with the deepening development of natural product pharmacology, Gao Sheng Quafen has gradually become a hot topic in neuroprotection, anti-inflammation, anti-tumor, and cardiovascular disease research due to its unique bioactivity and good oral absorption. It can cross the blood-brain barrier, regulate nerve cell function, and show potential for improving cognitive impairment; At the same time, it demonstrates complex regulatory effects with multiple targets and pathways in antioxidant, anti-inflammatory, and anti-cancer mechanisms. This paper will systematically review the chemical structure, origin, pharmacological activity, mechanism of action, druggability, and clinical application prospects of Gaosheng Caofenol, aiming to provide a theoretical basis and research reference for further drug development and clinical translation.
Gaetholin belongs to the flavanoid class of compounds, with a molecular formula of C16H14O6 and a molecular weight of 302.2820. Its structural core is a typical flavanone backbone, containing multiple hydroxyl and methoxy substituents, giving it excellent bioactivity. The LogP value of high santofolol is 2.1918, indicating moderate lipid solubility, which facilitates cell membrane penetration and distribution in vivo. The topological polar surface area (TPSA) was 96.22 Ų, indicating good balance in both polar and non-polar environments, which is beneficial for oral absorption and blood-brain barrier penetration. The water solubility is 0.3047, indicating low water solubility but sufficient to support bioavailability. In vitro safety assessment, high saline phenol showed no hERG channel inhibitory activity, with an Ames-induced mutagenic test value of 0.6, indicating a low genotoxicity risk.
High Esthor Phosphol is mainly found in various bitter herbaceous plants, such as Eriodictyon spp. and flavon-rich plants. In traditional Chinese medicine and folk herbal remedies, these plants are often used to treat inflammation, neurodegenerative diseases, and cardiovascular diseases. High-salytic phenol extraction is usually done using organic solvent extraction methods, often using ethanol or methanol as solvents combined with ultrasound-assisted extraction to improve extraction efficiency. Subsequently, the structure was identified by liquid chromatography (HPLC) separation and purification, combined with mass spectrometry and nuclear magnetic resonance (NMR) technology. In recent years, green extraction technologies such as supercritical CO2 extraction and microwave-assisted extraction have also been applied to efficiently extract high-Saint Quaphenol, further improving purity and yield.
Glycophenol has good oral activity and the ability to penetrate the blood-brain barrier, allowing it to regulate neuronal function. Research shows that high-sangtifol enhances synapse-associated protein expression through NCOA4-mediated ferritin autophagy, thereby improving neuroplasticity and cognitive function. Additionally, by inhibiting NLRP3 inflammasome activity, it reduces neuroinflammatory responses and significantly improves memory impairment in mouse models. These results indicate that high holytholol has potential application value in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Glycerolol can activate the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, enhance the expression of intracellular antioxidant enzymes, and inhibit oxidative stress. Its protective effect on human endothelial cells is particularly significant, helping to prevent mitochondrial dysfunction, reduce reactive oxygen species (ROS) levels, lessen oxidative damage, and maintain the functional stability of vascular endothelium. This characteristic makes it of great significance in the prevention and treatment of cardiovascular diseases.
Gaosheng Quaol regulates inflammatory signaling pathways through multiple targets, especially by inhibiting the activation of NLRP3 inflammasomes, reducing the release of pro-inflammatory cytokines, and exerting significant anti-inflammatory effects. This mechanism is not only prominent in neurological diseases but also helps alleviate systemic inflammatory responses and promote tissue repair.
Gasheng Quafen induces cancer cell apoptosis by enhancing ROS activity, demonstrating good antitumor activity. In vitro experiments have shown that high-setholol can inhibit the survival and migration of androgen-resistant prostate cancer cells, suggesting its potential in prostate cancer treatment. Additionally, by regulating cell cycle and apoptosis-related proteins, it inhibits tumor cell proliferation and metastasis, offering broad anti-cancer application prospects.
Glycerolol inhibits platelet aggregation, with related targets including key molecules such as PTGS1, PTGS2, ITGA2B, ITGB3, P2RY12, TBXA2R, and PDE3A. This effect helps prevent thrombosis, reduces the risk of cardiovascular and cerebrovascular events, and demonstrates excellent cardiovascular protective potential.
Animal experiments showed that high-saline phenol exhibited anti-nociceptive activity in mice, which could reduce pain sensation, suggesting its value in pain management and neuropathological pain treatment.
The multiple pharmacological effects of Gasheng Tithol are attributed to its ability to regulate multiple targets and multiple signaling pathways. It promotes iron homeostasis regulation through NCOA4-mediated ferritin autophagy, enhancing synaptic function in nerve cells. Inhibits NLRP3 inflammasome activity, reduces the release of inflammatory mediators, and alleviates nerve and systemic inflammation. Activates the Nrf2 pathway, enhances antioxidant defenses, and protects cells from oxidative damage. The anticancer mechanism mainly relies on ROS-induced apoptosis and inhibition of tumor cell migration. The anti-platelet aggregation effect involves key platelet activation targets such as PTGS1/2 and P2RY12, regulating platelet function and thrombosis formation. Additionally, the protective effect of high sacrophilol on mitochondrial function helps maintain cellular energy metabolism and reduce apoptosis.
The molecular weight of high salytifol is moderate (302.2820), with a LogP value of 2.1918, meeting the lipophilic requirements for oral medications, which is beneficial for intestinal absorption. The TPSA was 96.22, indicating good balance in polar and non-polar environments, supporting its ability to penetrate the blood-brain barrier. It has low water solubility (0.3047), which may affect its bioavailability, but can be improved through formulation optimization. It has good in vitro safety, with no hERG channel suppression. Ames test results show low genotoxicity risk and high safety. Pharmacokinetic studies have shown that Gao Sheng Cao Phenol is rapidly absorbed orally and can effectively distribute to brain tissue, giving it strong central nervous system potential. Its metabolic pathway mainly involves liver enzyme systems, and the activity and clearance rates of these metabolites require further research.
With its multi-target and multi-mechanism pharmacological activity, Gao Shenglu Fenfurol shows broad clinical application prospects in neurodegenerative diseases, inflammatory diseases, cancer, and cardiovascular diseases. Especially in cognitive disorders such as Alzheimer's and Parkinson's, it improves neurological function by regulating iron homeostasis and inhibiting inflammasomes, offering potential disease-modifying effects. Its anti-cancer and antiplatelet aggregation activities offer new ideas for cancer treatment and cardiovascular disease prevention. In the future, it is necessary to strengthen pharmacokinetics, toxicology, and preclinical evaluations, optimize formulation design, and advance it toward the clinical trial stage. In addition, combining modern medicinal chemistry and biotechnology to develop high-sanctioned fenolol derivatives and compound formulations to enhance efficacy and safety will be an important research direction.
As a natural flavonoid with unique biological activity, Gaosheng Quafenol demonstrates broad pharmacological potential in multiple fields such as neuroprotection, anti-inflammation, anti-cancer, and cardiovascular diseases due to its excellent oral activity and blood-brain barrier penetration. Its multi-target, multi-mechanism mode of action provides a valuable example for the development of natural product drugs. In the future, through in-depth mechanistic research, pharmacokinetic optimization, and clinical translational studies, Gao Sheng Cao Fenol is expected to become a new generation of multifunctional therapeutic drugs, bringing new breakthroughs in the prevention and treatment of related diseases.
Shenshuai
Wenjing
Hedandan
