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Product name: Yuankanin
Synonym name: Genkwanin 5-O-primeveroside
Catalogue No.: BP4692
Cas No.: 77099-20-8
Formula: C27H30O14
Mol Weight: 578.523
Botanical Source:
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
217.9700
-.1496
-.1535
1.6444
.4540
.1606
Low
77.6223
4.5452
Yes
No
No
No
Yes
No
0.6
Yes
Yes
Yes
Yes
Yuankanin (CAS No.: 77099-20-8) is a natural flavonoid glycoside compound with the chemical structure of genkwanin-5-glycoside, and its glycoside group consists of xylose and glucose. As a natural product with potential pharmacological activity, coriander glycoside is mainly isolated from the above-ground methanol extract of Gnidia involucrata, a plant in the Thymelaeaceae family. In recent years, with the deepening of pharmacological research on natural products, coriander glycoside has gradually become a research hotspot in the field of drug development due to its remarkable anti-inflammatory activity and multi-target regulatory effects.
Anti-inflammatory response is a key link in the pathogenesis of various diseases, involving complex regulation of various cytokines and signaling pathways. Coriander glycoside demonstrates excellent anti-inflammatory effects by modulating key targets including IL-6, STAT3, CASP1, TRPV1, PTGS1, TNF, TRPA1, NOS2, PTGS2, and NFKB1, indicating its potential application value in the treatment of inflammation-related diseases. This paper will systematically review the chemical structure and physicochemical properties of coriander glycoside, plant origin and extraction methods, pharmacological activity and mechanism of action, druggability evaluation, and pharmacokinetic characteristics, and look ahead to its clinical application prospects, aiming to provide a theoretical basis and research direction for subsequent development of natural product drugs.
The chemical structure of coriander glycoside belongs to the flavonoid compounds, specifically genkwanin-5-glycosides, with the sugar component composed of xylose and glucose. Its molecular formula is C_27H_30O_14, and its molecular weight is 578.5230. The structural features of this compound include the benzene ring and pyranan ring system in the flavonoid nucleus, with five hydroxyl groups glycosylated to impart strong water solubility and biological activity.
In terms of physicochemical properties, coriander has a LogP value of -0.1496, indicating strong hydrophilicity, water solubility of 1.6444, good water solubility, and beneficial absorption and distribution in the body. Its topological polar surface area (TPSA) is 217.9700, and a higher TPSA value is usually associated with lower cell membrane permeability, suggesting limited transmembrane capability. The low permeability of the blood-brain barrier (BBB) indicates that coriander has difficulty entering the central nervous system, reducing the risk of central side effects. The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames test result was 0.6, indicating a low genotoxicity risk and a solid safety foundation.
In summary, the chemical structure and physicochemical properties of colangroside provide a solid foundation for its use as a drug molecule, especially in the development of anti-inflammatory drugs, where hydrophilicity and safety are important considerations.
Coriander glycoside mainly comes from the above-ground parts of Gnidia involucrata, a plant in the Thymelaeaceae family. Gnidia involucrata is widely distributed in parts of Africa and has traditionally been used to treat various inflammatory diseases and infections. Its medicinal value has gradually been confirmed by modern science.
The extraction method usually uses methanol as the solvent to extract the above-ground parts of plants. The specific steps include: drying and crushing the collected plant material, then performing multiple reflux or ultrasound-assisted extraction using 80%-100% methanol. After filtration and concentration, the extract is separated and purified using liquid-liquid partitioning, column chromatography (such as silica gel columns, C18 reversed-phase columns), and high-performance liquid chromatography (HPLC), ultimately obtaining high-purity coriander glycoside.
In recent years, with advances in extraction technology, green and efficient methods such as supercritical fluid extraction and microwave-assisted extraction have also been attempted for coriander extraction, significantly improving extraction efficiency and purity, reducing the use of organic solvents, and meeting the environmental requirements of modern natural drug development.
The pharmacological activity of coriander glycoside mainly focuses on anti-inflammatory effects, but there are also preliminary research reports in antioxidant and antitumor aspects.
A large number of in vitro cell models and animal experiments have shown that coriander glycoside can significantly inhibit the production and release of inflammatory mediators. Its targets include various inflammation-related factors, including pro-inflammatory cytokines IL-6 and TNF-α, the inflammatory signaling transduction molecule STAT3, inflammation-related enzymes PTGS1 (COX-1), PTGS2 (COX-2), NOS2 (iNOS), as well as inflammation-mediated ion channels TRPV1 and TRPA1.
In macrophage and monocyte models, coriander glycoside can inhibit LPS-induced IL-6 and TNF-α expression, reducing inflammatory responses. In animal inflammation models such as plantar swelling and inflammatory pain models, coriander glycoside exhibits significant anti-inflammatory and analgesic effects, suggesting potential therapeutic value for inflammatory diseases like arthritis and inflammatory bowel disease.
Some studies have shown that colangin has certain antioxidant activity, can scavenge free radicals, and reduce oxidative stress damage. In terms of antitumor effects, coriander glycoside regulates the apoptosis-related proteins CASP1 and NF-κB signaling pathways, inhibiting tumor cell proliferation and promoting apoptosis, though the related mechanisms still require further research.
The anti-inflammatory mechanism of colangroside involves multiple signaling pathways and key molecule regulation, reflecting its multi-target and multi-mechanism pharmacological characteristics.
Colangaloside can significantly downregulate the expression levels of pro-inflammatory cytokines IL-6 and TNF-α. IL-6, as an important mediator in inflammatory responses, participates in the activation of immune cells and amplification of inflammatory signals; TNF-α is a key initiator of inflammatory responses. Coriander glycoside reduces inflammatory responses by inhibiting the production of these cytokines.
STAT3 is a core transcription factor in the IL-6 signaling pathway and is involved in regulating the expression of inflammatory genes. Coriander glycoside can inhibit the phosphorylation activation of STAT3, blocking its nuclear transcriptional activity and thereby suppressing the expression of inflammation-related genes.
NF-κB (NFKB1) is another key inflammatory signal transduction molecule, regulating the expression of various inflammatory factors and enzymes. Colangroside reduces the expression of inflammatory enzymes such as PTGS2 (COX-2) and NOS2 (iNOS) by inhibiting NF-κB activation, thereby decreasing the synthesis of inflammatory mediators.
PTGS1 (COX-1) and PTGS2 (COX-2) catalyze the synthesis of prostaglandins and are important enzymes in inflammatory responses. Coriander glycoside inhibits the activity of these two enzymes, reducing the production of inflammatory mediators.
TRPV1 and TRPA1 are key ion channels in inflammatory pain, regulating neuronal excitability and pain conduction. Colangaloside regulates these two channels, helping to relieve inflammatory pain.
CASP1 (caspase-1) plays an important role in inflammatory cell death (pyroptosis). Colangaloside regulates CASP1 activity, influences the apoptosis of inflammatory cells, and reduces tissue damage.
In summary, coriander glycoside exerts its anti-inflammatory and related pharmacological effects through multi-target and multi-pathway synergistic effects, reflecting the complex bioregulatory properties of natural products.
The druggability evaluation of coriander includes physicochemical properties, in vivo absorption distribution, metabolic excretion (ADME) characteristics, and safety assessment.
The molecular weight of coriander is 578.5230, slightly above the ideal range for traditional oral drugs (<500), but still within acceptable limits. Its LogP value is -0.1496, indicating strong hydrophilicity and good water solubility, which is beneficial for formulation development. A higher TPSA value suggests lower cell membrane permeability, which may affect oral bioavailability.
Currently, in vivo pharmacokinetic research on coriander glycoside is relatively limited. Based on its physicochemical properties, it is speculated that oral absorption may be limited, and the blood-brain barrier permeability is low, indicating that it mainly acts on peripheral tissues. In the future, systematic in vivo pharmacokinetic studies, including absorption rate, volume of distribution, metabolic pathways, and excretion modes, are needed to guide dosage form design and administration regimen optimization.
The hERG channel inhibition test was negative, indicating that coriander has a lower risk of cardiotoxicity. The Ames test result was 0.6, indicating a low genotoxicity risk and a solid safety foundation. Combining its natural sources and traditional usage history, coriander glycoside has good safety potential.
As a multi-target anti-inflammatory natural product, coriander glycoside has broad clinical application potential. Inflammation is the common pathological basis for various chronic diseases such as rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, and metabolic syndrome. Coriander glycoside is expected to become an effective therapeutic candidate for these diseases by regulating key inflammatory factors and signaling pathways.
Moreover, the antioxidant and antitumor potential of coriander provides possibilities for expanding its application fields, especially in the regulation of the tumor-related inflammatory microenvironment. In the future, its pharmacokinetics, toxicology, and preclinical efficacy evaluation should be strengthened to promote its clinical translation.
In terms of drug formulations, given the water solubility and membrane permeability of coriander glycoside, developing suitable delivery routes (such as oral sustained-release formulations and local delivery systems) and nanocarrier technologies will help improve bioavailability and therapeutic efficacy.
In summary, colangroside is a natural product with multi-target anti-inflammatory activity and has promising prospects for drug development. In the future, by integrating modern medicinal chemistry, pharmacology, and formulation technologies, it is expected to translate clinical applications and enrich the treatment options for anti-inflammatory drugs.
Coriander, a natural flavonoid glycoside derived from Gnidia involucrata, demonstrates remarkable anti-inflammatory activity and multi-target regulatory capability due to its unique chemical structure and excellent physicochemical properties. Its mechanism of action encompasses multi-level regulation of inflammatory cytokines, signal transduction pathways, inflammatory enzymes, and ion channels, reflecting the complex and effective bioregulatory properties of natural products.
Druggivability evaluations show colangin has good water solubility and safety, but its cell membrane permeability and oral bioavailability still need optimization. In the future, pharmacokinetic and toxicological research should be strengthened, combined with modern formulation technologies, to promote preclinical research and clinical trials.
In summary, coriander glycoside, as a multifunctional natural product, has broad prospects for anti-inflammatory and related disease treatments. In-depth exploration of its pharmacological mechanisms and optimization of drug properties will provide an important example for the development of natural product drugs, supporting the research and application of novel anti-inflammatory drugs.
Shenshuai
Wenjing
Hedandan
