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Product name: Lotaustralin
Synonym name: (2RS)-Lotaustralin; 534-67-8; (2R)-Lotaustralin
Catalogue No.: BP4191
Cas No.: 1973415-50-7
Formula: C11H19NO6
Mol Weight: 261.274
Botanical Source:
Type of Compound:
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
123.1700
-.8450
-.8453
59.8040
.5130
.6950
High
18.9553
4.2792
Yes
No
No
No
Yes
No
0.0
Yes
Yes
Yes
Yes
Lotaustralin ((2RS)-Lotaustralin) is a natural product with significant biological activity that has attracted widespread attention in the field of natural product pharmacology in recent years. As an important class of plant-derived secondary metabolites, Cymrodin has become a hot topic in drug development and disease prevention research due to its unique chemical structure and diverse biological functions, especially its potential application value in antioxidant fields. As a key pathological mechanism in various chronic diseases and aging processes, oxidative stress has prompted scientists to continuously explore natural antioxidants in hopes of discovering highly effective and low-toxicity drug candidates. Baimai Gen Glycoside demonstrates promising clinical application prospects due to its excellent antioxidant properties and favorable druggability parameters.
This paper will systematically review the chemical structure and physicochemical properties of Baimai Genin (Bai Mai Gen Glycoside), plant origin, and extraction methods, delve into its pharmacological activity and mechanism of action, and, combined with druggability evaluation and pharmacokinetic data, anticipate its potential and development direction in clinical application, aiming to provide comprehensive theoretical support and practical guidance for related research.
The chemical name of Lotaustralin is (2RS)-Lotaustralin, with the molecular formula C12H19NO6 and a molecular weight of 261.2740. Its structure belongs to the cyanoside compounds, featuring typical cyano-(–CN) functional groups and glycoside structural units. The stereoscopic configuration of this compound is an R/S mixture with two carbon atoms, exhibiting certain stereoisomerism.
In terms of physicochemical properties, the LogP value of Bai Mai Gen Wine is -0.8450, indicating strong hydrophilicity and good water solubility (59.8040 mg/mL), which is beneficial for absorption and distribution in organisms. Its polar surface area (TPSA) is 123.1700 Ų, indicating that the molecule has high polarity, which may affect its ability to penetrate cell membranes. Notably, Baimai Genin has a high ability to penetrate the blood-brain barrier, offering possibilities for treating central nervous system diseases. Additionally, this compound did not exhibit hERG channel inhibitory activity, indicating a low cardiotoxicity risk. The Ames test result was 0.0, indicating no significant mutagenicity and good safety.
Root-based glycoside is mainly found in various traditional Chinese medicinal materials and wild plants, with Lotaustralin (Lotaustralin genus) being the primary source. These plants are widely distributed in temperate and subtropical regions of Asia and have long been used in folk herbal medicine to treat various diseases. The content of Bai Mai Root Glycoside is greatly influenced by plant species, growth environment, harvest time, and processing techniques.
The extraction process typically uses solvent extraction, with commonly used solvents including ethanol, water, and their mixed solvent systems. Modern extraction techniques such as ultrasound-assisted extraction, microwave-assisted extraction, and high-performance liquid chromatography (HPLC) purification have been widely applied for the extraction and separation of hundred-vein root glycoside. The specific steps generally include: plant drying and crushing→ solvent extraction → filtrate concentration→ crude extract separation and purification→ pure product identification. During purification, Thin-layer chromatography (TLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) technologies are used to confirm the structure and detect the purity of hundred-vein root sin.
Pharmacological activity studies of Baimaiginin mainly focus on its antioxidant function and its potential for disease prevention and treatment. Numerous in vitro and in vivo experiments have shown that Baimai root glycoside can effectively eliminate free radicals, reduce oxidative stress damage to cells, and protect cellular functional integrity.
Antioxidant activity
Cyprin exerts antioxidant effects through multiple mechanisms, including direct scavenging of reactive oxygen species (ROS), enhancing endogenous antioxidant enzyme activity (such as SOD, CAT, GPX), and regulating the expression of antioxidant-related genes. It demonstrated significant effects in DPPH radical scavenging experiments, ABTS radical scavenging experiments, and oxidative damage repair in cell models.
Anti-inflammatory effects
Oxidative stress is closely related to inflammatory responses. Bai Mai Gen Ding demonstrates certain anti-inflammatory activity by inhibiting the release of inflammatory factors and regulating related signaling pathways. Related studies have shown that it can downregulate the expression of matrix metalloproteinases such as MMP1 and MMP3, reducing tissue damage.
Neuroprotective effects
Given that Cymoside has excellent blood-brain barrier penetration ability, researchers are exploring its application in neurodegenerative diseases. Preliminary studies have shown that Cynocytri can reduce oxidative damage to nerve cells, promote cell survival, and has potential neuroprotective effects.
Other potential activities
Some studies suggest that Baimai Genin also has certain potential in cardiovascular protection, anti-tumor, and immune regulation, but the related mechanisms still need further clarification.
The biological effects of Cynoside mainly occur by regulating various antioxidant-related targets. Key targets include:
The mechanism of action of Baimai root glycoside reflects its multi-target, multi-pathway coordinated regulation, directly scavenging free radicals while activating the intracellular antioxidant defense system, forming an effective antioxidant network.
From the perspective of druggability parameters, Baimai Genin has good potential for drug development. Its molecular weight is 261.2740, which fits the ideal range of Lipinski's rules. A negative LogP value (-0.8450) indicates good hydrophilicity, which is beneficial for dissolution and absorption in the body. The TPSA value was 123.1700, indicating moderate polarity, capable of balancing biofilm penetration and water solubility.
Cylindrin demonstrates high blood-brain barrier penetration ability, supporting its potential application in central nervous system diseases. The hERG channel inhibition test results were negative, indicating a low risk of cardiotoxicity and good safety. The negative results of the Ames trial further confirm its non-mutagenic nature, making it suitable for long-term clinical use.
Pharmacokinetics: Although metabolic and kinetic data from the system are currently limited, preliminary studies show that Centadrin is well absorbed orally and widely distributed, especially enriched in brain tissue. Its metabolic pathway may involve glycoside hydrolysis and oxidation reactions in liver enzyme systems, and the metabolites still require further identification. Excretion mainly occurs via the kidneys and bile pathways, with a moderate half-life, suitable for clinical administration.
As a natural antioxidant, Bai Mai Root Glycoside has broad clinical application potential. Its multiple activities in antioxidant, anti-inflammatory, and neuroprotective aspects make it especially suitable for adjunctive treatment and prevention of oxidative stress-related diseases.
Neurodegenerative diseases
Among the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, oxidative stress plays an important role. Cymédrin has excellent blood-brain barrier penetration and neuroprotective effects, providing a theoretical basis for its role as a candidate drug for neurological diseases.
Cardiovascular diseases
Oxidative stress is an important pathological factor in cardiovascular diseases such as atherosclerosis and hypertension. Cytetraxin, by regulating MMPs and antioxidant enzymes, may reduce vascular damage and improve vascular function.
Skin protection and beauty
The regulatory effect of Baimai Genin on tyrosinase suggests its potential in preventing and treating skin photoaging and pigmentation, and it could be developed into a functional skincare ingredient in the future.
Other potential applications
Including diabetic complications, adjuvant therapy for tumors, and immunomodulation, the multi-target mechanism of Baimai Genin offers possibilities for diversified development.
Future research should focus on preclinical safety evaluation, pharmacokinetic optimization, formulation development, and clinical trial design for Baimaigengin, promoting its translation from laboratory research to clinical application.
As a natural product with a unique structure and significant antioxidant activity, Baimai Genin shows broad prospects for drug development. Its multi-target, multi-mechanism antioxidant effects provide new approaches for treating various oxidative stress-related diseases. Combined with favorable druggability parameters and safety data, Baimai Genin is expected to become an important candidate in the field of natural antioxidants.
In the future, deepening research on its mechanism of action, improving pharmacokinetics and toxicological evaluations, and conducting systematic preclinical and clinical studies will lay a solid foundation for the drug development and clinical application of Baimai Gen Side, promoting its widespread application in natural product pharmacology and modern medicine.
Shenshuai
Wenjing
Hedandan
