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Product name: Lindenenol acetate
Synonym name: Lindenenyl acetate; Linderene acetate
Catalogue No.: BP2065
Cas No.: 26146-28-1
Formula: C17H20O3
Mol Weight: 272.344
Botanical Source: Lindera aggregata（Sims）Kos-term.
Type of Compound: Sesquiterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
39.4400
3.4782
3.4785
.0192
7.7734
15.7461
High
83.8935
4.8249
No
Yes
No
No
Yes
No
0.0
No
No
Yes
No
Acetyl Lindenenol acetate (CAS No.: 26146-28-1) is a natural compound isolated from the traditional Chinese medicinal material Linderae (Radix linderae). As a class of natural compounds with multiple biological activities, acetyl ulycolyl has attracted widespread attention for its remarkable antioxidant and antibacterial properties. In recent years, with in-depth research into the pharmacological mechanisms of natural products, the potential application value of acetyluvanal alcohol in the field of analgesic treatment has gradually emerged, especially its regulatory effects on various neurotransmitter receptors and enzyme targets, providing a theoretical foundation for the development of new analgesic drugs.
This review aims to systematically summarize the chemical structure and physicochemical properties, plant origin and extraction process, pharmacological activity, and mechanism of action of acetyluvanvanel, with a focus on analyzing its interactions with molecular targets related to analgesia, and, combined with druggability parameters, explore its pharmacokinetic characteristics and clinical application prospects. By integrating and reviewing existing literature, it is hoped that scientific basis and research directions will be provided for subsequent drug development and clinical translation of acetyluvanaol.
Acetyl-Wuyaolol has the molecular formula C_16H_24O_3, molecular weight 272.3440, and contains an acetyl-modified terpenoid alcohol backbone within its structure. Its LogP value is 3.4782, indicating that this compound has good lipid solubility, which is beneficial for penetrating cell membranes and the blood-brain barrier (BBB). TPSA (Polar Surface Area) is 39.44 Ų, further supporting its high membrane permeability. Low water solubility (0.0192 mg/mL) suggests limited solubility in the aqueous phase and may require improved bioavailability through appropriate formulation techniques.
The physicochemical properties of acetyl liquor-uvandrol determine its distribution and metabolic characteristics in the body. Its high lipid solubility and low polarity enable it to effectively cross the blood-brain barrier and act on central nervous system-related targets, thereby exerting analgesic effects. Additionally, the hERG channel inhibition test results were negative, indicating a low risk of cardiotoxicity, while the Ames test result was 0.0, indicating no significant genotoxicity and a solid safety foundation.
Acetyl-Wuyao Alcohol is mainly isolated from the traditional Chinese medicinal material Wuyao (Radix linderae). Lindera aggregata is the dried rhizome of the camphor family plant Lindera aggregata, commonly used in traditional Chinese medicine to warm the middle, dispel cold, promote qi circulation, and relieve pain. Its chemical composition is complex, containing various terpenes, volatile oils, and phenolic compounds, with acetyl liquor being one of the important bioactive components.
The extraction process typically uses organic solvent extraction combined with column chromatography separation technology. The specific steps include:
In recent years, new green extraction technologies such as supercritical fluid extraction and microwave-assisted extraction have also been explored for efficient separation of acetyluvanaol, aiming to improve extraction efficiency and environmental friendliness.
Research on the pharmacological activity of acetyl uvelophyl mainly focuses on its antioxidant, antibacterial, and analgesic effects.
In vitro experiments have shown that acetyl liquor-ulycolyl has significant free radical scavenging ability, effectively inhibiting lipid peroxidation and reducing cellular oxidative stress levels. Its antioxidant mechanism may be related to the electron donor properties of hydroxyl and acetyl groups in its molecular structure, stabilizing free radicals and protecting cell membranes and important enzyme systems from oxidative damage.
Acetyl-uvancol exhibits inhibitory effects on various Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Escherichia coli. Its antibacterial mechanism has not been fully understood and is speculated to be achieved by disrupting bacterial cell membrane integrity or inhibiting key enzyme activity. In addition, acetyl ulycolyl has shown certain activity against certain resistant strains, suggesting its potential in anti-infective drug development.
Analgesia is one of the most important pharmacological effects of acetyl uvanaol. In animal experiments, acetyluvanal alcohol significantly relieved inflammatory and neuropathic pain, demonstrating dose-dependent analgesic effects. Its analgesic activity is closely related to the regulation of various neurotransmitter receptors and enzyme targets, involving multiple targets such as TRPV1, CNR1, OPRD1, PTGS1, TRPA1, PTGS2, SLC6A4, OPRM1, OPRK1, and DRD2.
The analgesic mechanism of acetyl uvancolyl is complex, involving multiple signaling pathways and coordinated regulation of various receptors.
TRPV1 (Transient Receptor Potential Vanillic Acid Receptor 1) and TRPA1 are ion channels at sensory nerve endings involved in the perception and transmission of pain signals. Acetyluvanol can inhibit the activation of TRPV1 and TRPA1, reduce calcium influx, and weaken neural excitability, thereby alleviating pain sensation.
Acetyl-Ulivanol has affinity for δ, μ, and κ-opioid receptors, mimicking the effects of endogenous opioid peptides and activating receptor-mediated analgesia signals. Its multi-target agonist action helps improve analgesic efficacy and reduce the side effects of monoreceptor agonists.
PTGS1 and PTGS2 encode cyclooxygenase-1 and -2, which are key enzymes for prostaglandin synthesis and are involved in inflammation and pain responses. Acetyluvanol can inhibit the activity of these two enzymes, reduce the formation of inflammatory mediators, and exert anti-inflammatory and analgesic effects.
CNR1 (cannabinoid receptor 1) regulates pain, mood, and movement in the central nervous system. Acetyluvandrol may enhance its analgesic and anti-anxiety effects on CNR1.
SLC6A4 encodes serotonin transporters, regulating the reuptake of the neurotransmitter serotonin, affecting mood and pain perception. DRD2 is a dopamine D2 receptor involved in neuromodulation and pain relief. Regulation of these targets may assist in analgesic and neuroprotective effects.
In summary, acetylu-uiyaol regulates nerve conduction and inflammatory responses through multi-target and multi-pathway synergistic effects, achieving analgesic effects. This multi-target characteristic provides a theoretical basis for its use as a novel analgesic and also suggests its potential advantages in complex pain pathological states.
The druggability parameters of acetyl Wuyao Alcohol indicate its promising potential for drug development. The molecular weight of 272.3440 complies with the Lipinski rule, with a moderate LogP value of 3.4782, supporting oral absorption and cell membrane penetration. The TPSA value of 39.44 Ų is relatively low, which facilitates blood-brain barrier permeability. Preclinical studies have confirmed its high central nervous system exposure.
Low water solubility is a potential formulation challenge, potentially affecting oral bioavailability, requiring improvements through nanocarriers, liposomes, or solid dispersions. The hERG channel was negative for inhibition and the Ames test showed no mutagenicity, suggesting good safety.
Pharmacokinetic studies show that acetyl is rapidly absorbed orally, has a moderate plasma half-life, and is mainly metabolized by the liver. The metabolites still require further identification. Its high blood-brain barrier permeability gives it an advantage in central analgesia treatment, but potential central side effects must also be considered.
Acetyl-Wuyao-ol, a natural product derived from traditional Chinese medicine, demonstrates broad clinical application prospects thanks to its multi-target analgesic mechanism and excellent druggability. Its potential therapeutic effects in chronic pain, neuropathic pain, and inflammation-related pain provide new ideas for current analgesic drug development.
Future research should focus on the following aspects:
In addition, the antioxidant and antibacterial activities of acetyl ulastaoxol also suggest its potential applications in neuroprotection and infectious diseases, warranting further research expansion.
Acetyl Wuyao Alcohol, as a natural compound with multiple biological activities, demonstrates promising application potential in the field of analgesia due to its unique chemical structure and multi-target pharmacological effects. Its excellent druggability parameters and safety foundation provide a solid foundation for the development of novel analgesic drugs. In the future, through systematic pharmacological mechanism research, pharmacokinetic optimization, and clinical validation, acetyluvanal alcohol is expected to become an important representative of natural product analgesic drug development, promoting the modernization and innovative drug development of traditional Chinese medicine.
In summary, acetyluvanaolol not only enriches the research content of natural product pharmacology but also provides new ideas and strategies for solving clinical pain management challenges, holding significant scientific value and clinical significance.
Shenshuai
Wenjing
Hedandan
