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Product name: Usaramine N-oxide
Synonym name:
Catalogue No.: BP4092
Cas No.: 117020-54-9
Formula: C18H25NO7
Mol Weight: 367.398
Botanical Source: Crotalaria pallida Ait.
Physical Description:
Type of Compound: Alkaloids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
HPLC of Usaramine N-oxide
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
116.1200
-.9771
-.9766
140.0428
.9519
2.3527
Low
48.9985
5.8392
No
No
No
No
Yes
No
1.2
Yes
Yes
Yes
Yes
Usaramine N-oxide (CAS No.: 117020-54-9) is a natural pyrrolizine alkaloid isolated from the plant Crotalaria pallida, a plant of the genus Crotalaria. As a derivative of alkane compounds from Qianliguang, the Guangca Wild Lily Alkali nitrogen oxide has a unique chemical structure and diverse biological activities, especially showing significant anti-inflammatory and potential antitumor effects. In recent years, with the continuous development of natural product pharmacology, Guangca Wild Lily Alkali Nitrogen Oxide has gradually become a research hotspot in the field of drug development due to its multi-target mechanism of action and excellent safety profile.
This review aims to systematically summarize the chemical structure, physicochemical properties, plant origin, and extraction methods of the Physicolyx Wild Lily Alkali nitrogen oxide, focusing on its pharmacological activity and mechanism of action, exploring its druggability and pharmacokinetic characteristics, and finally looking ahead to its clinical application potential and future research directions, providing reference and inspiration for researchers in related fields.
Phylloli Phyllusine Nitrogen Oxide is a complex organic heterotricyclic compound belonging to the pyrrolizine alkaloid family. Its molecular formula is C_18H_27N_1O_6, and its molecular weight is 367.3980. Structurally, the nitrogen oxides of the Guangcalyx wild lily alkali form the Qianliguang alkane backbone, with two additional hydroxyl substituents located at positions 12 and 18, respectively; At positions 11 and 16, it carries two oxidation groups and contains one N-oxidation substituent. This structural feature gives the compound a high polarity and complex three-dimensional conformation.
In terms of physicochemical properties, the LogP value of the nitrogen oxides of Phyllus Lily alkali was -0.9771, indicating strong hydrophilicity, with water solubility reaching 140.0428 mg/mL, indicating good water solubility. Its topological pole surface area (TPSA) is 116.1200 Ų, indicating that the molecule has a high number of polar functional groups, which is favorable for binding to biological macromolecules. The blood-brain barrier has low permeability, indicating limited penetration in the central nervous system. The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames mutagenicity test scored 1.2, indicating a low genotoxicity risk.
In summary, the Phyllus-Lye alkali nitrogen oxides, with their unique chemical structure and excellent physicochemical properties, provide a solid foundation for their biological activity and drug development.
The nitrogen oxides of Chromium Wild Lily Alkali mainly come from the plant Crotalaria pallida, which is widely distributed in tropical and subtropical regions and has traditionally been used in traditional Chinese medicine and folk herbal medicine to treat various diseases. Crotalaria pallida is rich in various pyrrolizine alkaloids, with the nitrogen oxide of Chlorocarya Wild Lily being one of the key components.
The extraction method usually uses dried whole plants or rhizomes as raw materials, first extracted with suitable polar solvents (such as methanol, ethanol, or ethyl acetate). After concentration, the extract is separated using acid-base extraction to separate alkaloid components. Subsequently, further purification was performed using column chromatography (such as silica gel columns and C18 reversed-phase columns) and high-performance liquid chromatography (HPLC) technology, ultimately yielding high-purity Physica wild lily alkali nitrogen oxides.
In recent years, the application of ultrasound-assisted extraction and microwave-assisted extraction technologies has improved extraction efficiency and purity, reduced solvent usage, and promoted large-scale preparation and research of this compound.
The nitrogen oxides of Phyllus lily were first noticed for their significant anti-inflammatory effects. Both in vitro and in vivo experiments have shown that this compound can significantly inhibit the release of inflammatory mediators such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and nitric oxide (NO). Its mechanism of suppressing inflammatory responses may be related to regulating the nuclear factor κB (NF-κB) signaling pathway, thereby alleviating tissue inflammatory damage.
In recent years, research on the nitrogen oxides of Phyllus Lily alkali in the field of antitumor has gradually increased. Multiple cell experiments have shown that this compound has significant inhibitory effects on various tumor cell lines (such as breast cancer, lung cancer, and liver cancer cells). Its antitumor effects manifest as inducing tumor cell apoptosis and inhibiting cell proliferation and migration ability.
In addition to anti-inflammatory and antitumor effects, the nitrogen oxides of Phylluscara Lilily also exhibit certain antioxidant and immunomodulatory activities. It further exerts protective effects by regulating oxidative stress-related enzymes and immune cell functions.
The pharmacological effects of Phyllium Wild Lily Alkali nitrogen oxides involve multiple signaling pathways and multiple molecular targets, reflecting its multi-target and multi-mechanism characteristics.
Phyllium Wild Lily alkaloid nitrogen oxides reduce pro-inflammatory factor expression and inflammatory response by inhibiting the NF-κB signaling pathway. Additionally, it regulates the activity of oxidative stress-related enzymes and reduces cellular damage.
In summary, the nitrogen oxides of Phyllus Lily alkali achieve anti-inflammatory and anti-tumor pharmacological effects through multi-target and multi-pathway synergistic effects.
The molecular weight of the Lycophax Wild Lily alkali nitrogen oxide is 367.3980, meeting the molecular weight requirements of the Lipinski rule. Its LogP value is -0.9771, indicating strong hydrophilicity, which may affect oral absorption and cell membrane permeability. TPSA is 116.1200, indicating that the molecule contains a high number of polar groups, which may limit membrane permeability but favors target binding.
It has good water solubility (140.0428 mg/mL), which is beneficial for formulation development and improved bioavailability. Low blood-brain barrier permeability indicates a lower risk of side effects in the central nervous system.
The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames test scored 1.2, indicating a low risk of genotoxicity and good safety.
Currently, pharmacokinetic research on the nitrogen oxides of Phyllus Lily Alkali is relatively limited. Based on its physicochemical properties, it is speculated that oral absorption may be limited and bioavailability may be enhanced through drug carriers or structural modifications. Its hydrophilicity and high polarity may cause rapid renal excretion, resulting in a shorter half-life.
Future research should focus on its distribution in vivo, metabolic pathways, and excretion mechanisms, optimizing administration methods and dosage form design.
Guangca wild lily alkali nitrogen oxides, with their remarkable anti-inflammatory and antitumor activities, demonstrate broad clinical application potential. Its multi-target mechanism of action is suitable for the treatment of complex diseases, especially in tumor microenvironment regulation and the treatment of inflammation-related tumors, offering unique advantages.
Future research directions include:
Moreover, with the development of natural product pharmacology and synthetic biology, the production process and drug development of Guangca Wild Lily alkali nitrogen oxides will be further optimized, promoting it as an important candidate for novel anti-inflammatory and anti-tumor drugs.
Chlorophyllaria alkaloid nitrogen oxides, as a natural pyrrolizine alkaloid derived from Crotalaria pallida, have become a hot topic in natural product pharmacological research due to their unique chemical structure and multi-target pharmacological activity. Its significant anti-inflammatory and antitumor mechanisms provide new ideas and candidate molecules for the treatment of related diseases.
Although pharmacokinetics and clinical application research are still in the early stages, their favorable druggability parameters and safety evaluation provide a solid foundation for subsequent research. In the future, through multidisciplinary collaboration, Guangca Wild Lily Alkaloid nitrogen oxides are expected to play an important role in the fields of anti-tumor and anti-inflammatory treatments, becoming a model for natural product drug development.
In summary, the nitrogen oxides of Guangca wild lily alkali not only enrich the chemical and pharmacological knowledge system of natural products, but also provide valuable resources for innovative drug development, warranting further in-depth research and development.
Shenshuai
Wenjing
Hedandan
