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Product name: 1,1,1,1-Kestohexose
Synonym name: Fructo-oligosaccharide DP6 / GF5；1,1,1,1-Kestohexaose; 1-(Fructofuranosyl)2 nystose
Catalogue No.: BP4063
Cas No.: 62512-19-0
Formula: C36H62O31
Mol Weight: 990.861
Botanical Source:
Physical Description: White powder
Type of Compound: Oligose
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
HPLC of 1,1,1,1-Kestohexose
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
506.1300
-4.4756
-4.4745
37.9777
.4249
.1710
Low
17.5158
6.5248
Yes
No
No
No
Yes
No
0.9
Yes
Yes
Yes
Yes
As people's awareness of health management and disease prevention continues to rise, prebiotics, as important natural products for regulating the gut microecology, have received widespread attention. Cane hexagose (1,1,1,1-Kestohexose, CAS No.: 62512-19-0) is an emerging natural polysaccharide compound. Due to its unique structure and significant bioactivity, it has become a hot topic in pharmacological research of natural products. Sucralose hexaccharide has good water solubility and low lipid solubility, a large molecular weight, and outstanding prebiotic function. It can promote the restoration of intestinal barrier function and the maintenance of immune homeostasis by regulating the gut microbiota and related immune signaling pathways. This paper aims to systematically review the chemical structure and physicochemical properties of sucrose hexatose, plant origin and extraction methods, pharmacological activity and mechanism, druggability evaluation and pharmacokinetic characteristics, and to anticipate its clinical application potential to provide a theoretical basis for subsequent basic and clinical research.
Sucra hexaccharide is a highly water-soluble polysaccharide compound with a complex molecular formula and a molecular weight of 990.8610. Its chemical structure is formed by multiple fructose units connected by specific glycosidic bonds, containing abundant hydroxyl groups that give it strong hydrophilicity. Its LogP value was -4.4756, indicating that sucrose hexaccharides are highly soluble in water but poorly soluble in lipid environments. The top Polar Surface Area (TPSA) reaches as high as 506.1300, reflecting the abundance of polar groups on its molecular surface, further supporting its strong water solubility. The water solubility index is 37.9777, making it suitable for biological activity in aqueous solutions. Sucralose has low blood-brain barrier permeability, suggesting its effect is mainly limited to the gastrointestinal system. The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames trial scored 0.9, indicating a low genotoxicity risk and a good safety profile.
Sucrose hexatose is mainly found in sugarcane (Saccharum officinarum) and its related sucrose by-products, with particularly abundant content in sugarcane juice and bagasse. Traditional extraction methods combine water extraction with alcohol precipitation, leveraging their high water solubility to obtain crude polysaccharide solutions through hot water extraction, followed by ethanol precipitation to remove low molecular weight impurities to obtain purer sucrose hexatose. The introduction of modern extraction technologies such as ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and membrane separation technology has significantly improved extraction efficiency and purity, while maximizing the preservation of biological activity. During extraction, temperature and pH must be controlled to prevent degradation of polysaccharide structures and loss of activity. Purification steps typically use column chromatography techniques, such as gel filtration and ion exchange columns, to further separate polysaccharide components of different molecular weights, ensuring product consistency and stability.
The pharmacological activity of sucrose hexacyus mainly focuses on their prebiotic function, selectively promoting the growth of beneficial gut microbiota such as Bifidobacterium spp., thereby improving the balance of the intestinal microecosystem. Multiple in vitro and animal studies have shown that sucrose hexacyls regulate gut microbiota composition and increase the production of short-chain fatty acids (SCFAs) such as acetic acid, propionic acid, and butyric acid, thereby exerting anti-inflammatory, immunomodulatory, and gut barrier repair effects.
In the inflammatory bowel disease (IBD) model, sucrose significantly reduced the expression of pro-inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), while increasing levels of anti-inflammatory factor IL-22 and reducing intestinal mucosal damage. Its regulation of intestinal tight junction proteins (such as OCLN, ZO1, CLDN1) helps restore the integrity of the intestinal barrier and prevents pathogens and toxins from penetrating. In addition, sucrose hexatose also shows the potential to regulate intestinal immune cell function, enhancing the body's defense against intestinal pathogenic microorganisms.
The prebiotic mechanism of sucrose hexagonis mainly operates through multiple signaling pathways. Its molecular targets include:
The synergistic effects of these targets have established a multi-layered network for regulating the gut microenvironment and immune function, providing a molecular basis for its prebiotic and potential therapeutic effects.
The druggability parameters of sucrose hexagonose indicate good safety and biocompatibility. Its low LogP and high TPSA values indicate that it is difficult to cross lipid membranes, limiting systemic absorption and meeting the pharmacological requirements of prebiotics mainly acting on the intestines. The blood-brain barrier has low penetration, reducing the risk of central nervous system side effects. The inhibition of the hERG channel and the Ames test's low mutagenicity further ensure its cardiac and genetic safety.
Pharmacokinetics, sucrose hexagonis is not degraded by digestive enzymes in the gastrointestinal tract but can reach the colon and be fermented and utilized by gut microbiota, producing short-chain fatty acids. Its absorption and metabolism mainly depend on gut microbial metabolism, with extremely low concentrations in systemic circulation, reducing potential systemic toxicity. Future research on in vivo pharmacokinetics is needed to clarify its metabolic pathways and excretion characteristics under different physiological states.
Based on the significant role of sucrose hexacan in regulating gut microbiota, repairing the intestinal barrier, and modulating immune responses, its application potential in various gut-related diseases is enormous. Especially in inflammatory bowel disease, irritable bowel syndrome, metabolic syndrome, and immunodeficiency, sucrose hexacan can serve as a safe and effective prebiotic supplement.
Future clinical research should focus on dose optimization, route of administration, and long-term safety evaluation. At the same time, combining modern omics techniques, the study deeply analyzes its effects on gut microecology and host metabolism. In addition, the synergistic application of sucrose hexatose with probiotics, as well as combined therapeutic strategies with other functional foods or drugs, also provide broad opportunities for clinical translation.
With the development of precision medicine and personalized nutrition, sucrose hexagonal acid is expected to become an important natural medicinal ingredient for regulating gut health and preventing related diseases, driving innovation and progress in the prebiotic field.
As a natural polysaccharide with a unique structure and significant biological activity, sucrose hexa-saccharide exhibits excellent prebiotic functions and broad pharmacological effects. It regulates the gut microecology and immune environment through multiple targets and pathways, promotes intestinal barrier repair, and has good safety and drug potential. Although systematic research on its pharmacokinetics and clinical efficacy is still insufficient, its application prospects in the prevention and treatment of intestinal diseases are very broad. In the future, it is necessary to strengthen basic and clinical research to promote sucrose hexatose from the laboratory to clinical practice, injecting new vitality into the development of natural product pharmacology and functional foods.
Shenshuai
Wenjing
Hedandan
