Product name: Curzerenone
Synonym name:
Catalogue No.: SBP03073
Cas No.: 20493-56-5
Formula: C₁₅H₁₈O₂
Mol Weight: 230.307
Botanical Source: Curcumae Rhizoma
Physical Description:
Type of Compound: Sesquiterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams
Inquire for bulk scale.

For Reference Standard and R&D, Not for Human Use Directly.

Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃

Introduction/Overview

Curzerenone (CAS No.: 20493-56-5) is a natural compound isolated from the essential oil of Curcuma zedoaria in Tibet, classified as a sesquiterpene compound. In recent years, as the importance of natural products in drug development has become increasingly prominent, curcuma ketone, due to its unique chemical structure and potential multi-target pharmacological activity, has gradually become a research hotspot in pharmacology and natural medicinal chemistry. Previous studies have shown that curcuma ketone inhibits various pathogenic microorganisms, especially showing mild inhibitory activity against Escherichia coli. Moreover, curvachul ketone may have potential therapeutic effects in various pathological conditions such as tumors, inflammation, and metabolic diseases by regulating key molecular targets. This paper aims to systematically review the chemical structure, sources, pharmacological activity, and mechanism of action of curvachu ketone, evaluate its druggability and clinical application prospects, and provide a theoretical basis for subsequent research and development.

Chemical structure and physicochemical properties

Curvacyl ketone has a molecular formula of C15H22O2 and a molecular weight of 230.30. Its chemical structure belongs to the sesquiterpene ketone class, featuring a typical terpene backbone and ketone functional groups. The LogP value is 2.81, indicating moderate lipid solubility and facilitating cell membrane penetration. Its topological pole surface area (TPSA) is 35.53 Ų, and the number of hydrogen bond receptors is 2, suggesting that it has certain bioavailability and good membrane permeability in vivo. The structure of curdron ketone contains a cyclic terpene skeleton and a ketone group, which imparts certain chemical stability and reactivity. Although safety indicators such as blood-brain barrier penetration, hepatotoxicity, cardiotoxicity, hERG inhibition, and mutagenicity (Ames assay) are still unclear, its physicochemical properties lay the foundation for its potential drug molecule.

Plant Origins and Extraction Methods

Curcuma ketone is mainly found in the essential oil components of Tibetan camphor leaf. Curcuma zedoaria is a plant in the ginger family, widely distributed in tropical and subtropical Asia. Traditionally, it has been used in traditional Chinese medicine and folk herbal medicine, with effects of promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain. Curvac ketone, as one of its volatile components, is usually extracted by distillation and then separated and purified using chromatography techniques (such as column chromatography, gas chromatography-mass spectrometry using GC-MS). In recent years, modern green extraction methods such as supercritical CO2 extraction technology and microwave-assisted extraction have also been applied to improve the extraction efficiency and purity of curcuma ketone. During the extraction process, temperature, time, and solvent selection have significant effects on the yield and stability of curcumone ketone.

Pharmacological activity research

Research on the pharmacological activity of curvachu ketone mainly focuses on antibacterial, anti-tumor, anti-inflammatory, and metabolic regulation.

Antibacterial activity

Curvachul ketone exhibits a mild inhibitory effect on E. coli, suggesting it has certain antibacterial potential. Although its activity against other bacteria has not been systematically reported, as a natural volatile oil component, curcumoneone may exert antibacterial effects by damaging bacterial cell membranes and interfering with bacterial metabolic pathways. Additionally, the regulatory effect of curvacylone on the bacterial lipopolysaccharide receptor TLR4 requires further study, which may provide a molecular basis for its antibacterial and anti-inflammatory activities.

Antitumor activity

Curvactin ketone shows potential regulatory ability for targets related to lung and colon cancer. Lung cancer-related targets include BCL2, MAPT, PIK3CA, EGFR, TP53, CDKN2A, ATP1A1, KRAS, MET, and WAX. Curterone may influence tumor cell proliferation, apoptosis, and migration by modulating these signaling pathways. Colon cancer-related targets include EGFR, KRAS, VEGFA, TP53, and CTNNB1. Curterone may exert anti-tumor effects by inhibiting epidermal growth factor receptor signaling, angiogenesis, and cell cycle regulation. Current in vitro cell experiments and molecular docking studies support curvachul ketone's potential for tumor cell suppression, but there is a lack of systematic in vivo validation and mechanism elucidation.

Anti-inflammatory and immunomodulatory

Curcumone may exert anti-inflammatory effects in inflammatory diseases such as rheumatoid arthritis by regulating inflammatory factors such as TNF, IL6, NFKB1, IL1B, and MMP3. Its inhibitory effect on the nuclear factor κB signaling pathway may be the key mechanism for reducing inflammatory responses and tissue destruction. Additionally, curvactin ketone modulates targets related to bacterial enteritis, such as TLR4, suggesting its potential application value in intestinal immunity and inflammation.

Metabolic disease regulation

In studies related to diabetic nephropathy, curcurdosterone may act as an antifibrotic, antioxidant, and anti-inflammatory molecule by regulating molecules such as transforming growth factor β1 (TGFB1), angiotensin II receptor type 1 (AGTR1), nuclear factor E2-related factor 2 (NFE2L2), vascular endothelial growth factor (VEGFA), and IL1B, thereby slowing the progression of kidney damage. Although related research is still in its early stages, the potential of curcumone in metabolic diseases deserves in-depth exploration.

Mechanism of action and molecular targets

The multi-target mechanism of curvac ketalone is a key basis for its pharmacological activity. Its regulation of tumor-related targets involves apoptosis regulatory proteins (such as BCL2, BAX), signal transduction molecules (EGFR, PIK3CA, KRAS, MET), tumor suppressor factors (TP53, CDKN2A), and others, which may exert anticancer effects by inducing tumor cell apoptosis, inhibiting proliferation and migration. The effect of curvac ketone on colon cancer targets, especially its inhibition of epidermal growth factor receptors and angiogenic factors, suggests it may suppress tumor angiogenesis and signaling.

In terms of inflammation and immune regulation, curvachu ketone reduces the expression of pro-inflammatory cytokines such as TNF, IL6, and IL1B by inhibiting the nuclear factor κB signaling pathway, thereby alleviating inflammatory responses. At the same time, its regulation of matrix metalloproteinase-3 (MMP3) helps prevent tissue damage and joint injury.

Curvacyl ketone regulates diabetic nephropathy-related targets, mainly involving anti-fibrotic and antioxidant signaling pathways such as TGFB1 and NFE2L2, which may protect kidney function by alleviating glomerular sclerosis and oxidative stress.

Additionally, the effects of curvaccinone on key bacterial enzymes such as DNA polymerase and β-lactamase remain unclear, but its regulation of the bacterial lipopolysaccharide receptor TLR4 suggests it may indirectly inhibit bacterial infection by modulating host immune responses.

Druggability evaluation and pharmacokinetics

Curvachu ketone has a molecular weight of 230.3, which fits the Lipinski rule molecular weight range, with a LogP of 2.81, indicating good lipid solubility and facilitating cell membrane penetration and oral absorption. Its TPSA is 35.53 Ų, with 2 hydrogen bond acceptors, both supporting its good bioavailability and in vivo distribution potential.

Currently, the blood-brain barrier penetration of curvactin ketone is not yet clear, but its moderate lipid solubility suggests it may have some central nervous system penetration ability. Safety indicators such as hepatotoxicity, cardiotoxicity, and hERG channel inhibition lack systematic data and require further evaluation through in vivo toxicology and pharmacokinetic studies.

Pharmacokinetics, curvactin ketone, as a natural volatile oil component, may exhibit rapid absorption and metabolism, but its specific absorption, distribution, metabolism, and excretion (ADME) parameters have not yet been systematically reported. In the future, combined with in vivo and in vitro experiments and using modern analytical techniques such as LC-MS/MS to clarify biological half-lives, metabolic pathways, and major metabolites, this should provide a basis for clinical development.

Prospects and outlooks for clinical applications

As a natural sesquiterpene ketone compound, with its multi-target and multi-pathway pharmacological activity, curcurone shows potential application value in anti-tumor, anti-inflammatory, antibacterial, and metabolic disease treatments. Especially in adjuvant therapy for malignant tumors such as lung and colon cancer, curvachu ketone may enhance the efficacy of existing treatments and reduce side effects by modulating key tumor signaling pathways.

In inflammatory diseases such as rheumatoid arthritis and bacterial enteritis, curvachu ketone is expected to become a new candidate for natural anti-inflammatory drugs by inhibiting inflammatory factors and modulating immune responses. Moreover, its antifibrotic and antioxidant effects in diabetic nephropathy offer new ideas for the treatment of chronic metabolic diseases.

However, the clinical application of curvactinone still faces many challenges. First, its safety and toxicological characteristics have not yet been systematically evaluated, requiring comprehensive in vivo toxicological studies. Second, the pharmacokinetic properties of curvactinone are unclear, limiting the optimization of dosage form design and administration regimens. Third, the lack of large-scale preclinical and clinical trial data makes it difficult to establish precise therapeutic effects and indications.

Future research should focus on deeply exploring the mechanism of action of curcumatilone, integrating modern molecular biology and medicinal chemistry methods to optimize its structure to enhance activity and safety. At the same time, systematic pharmacokinetic and toxicological studies are being conducted to promote clinical translation. The development of multi-target combination therapy strategies and nanocarrier delivery systems will also provide new opportunities for the clinical application of curvactinone.

Conclusion

Curvachu ketone, as an important active ingredient in Tibetan camphor leaf essential oil, demonstrates vast drug development potential due to its unique chemical structure and multi-target pharmacological activity. Its multiple roles in antibacterial, anti-tumor, anti-inflammatory, and metabolic diseases provide a valuable example for pharmacological research of natural products. Although the druggability and clinical application of curvactinone are still in the early stages, with further research, they are expected to become important candidates for new natural medicines. In the future, systematic pharmacological research and preclinical evaluation of curvactin ketone should be strengthened to promote its clinical application and provide new natural drug options for the treatment of related diseases.