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Product name: Parishin B
Synonym name:
Catalogue No.: BP1064
Cas No.: 174972-79-3
Formula: C32H40O19
Mol Weight: 728.653
Botanical Source: Gastrodia elata Bl.
Physical Description:
Type of Compound: Aliphatics
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Description:
Parishin B has good neuroprotective effects against brain disorders, it can prevent vascular dementia.
References:
Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.
Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.
METHODS AND RESULTS:
To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries. After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as Parishin B, parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification.
CONCLUSIONS:
These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.
HPLC of Parishin B
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
308.8900
-.8296
-2.5405
7.9268
.3506
.0538
Low
66.5327
4.8328
Yes
No
No
No
No
No
0.0
Yes
Yes
No
Yes
Shenshuai
Wenjing
Hedandan
