Macranthoidin A

Name: Macranthoidin A
Brand: Biopurify
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Catalogue No.： BP0908

CAS NO.: 140360-29-8

Purity: 98%

Brand: Biopurify

Botanical Source: Lonicerae flos

Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.

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Related diseases

Antiviral Liver fibrosis Chemical Liver Injury Drug-induced Liver Injury Inflammation

Related targets

Antiviral NA M2 NP PB2 PB1

Liver fibrosis BCL2 STAT3 MMP2 NFE2L2 SMAD3 TNF NOS2 MAPK8 PPARG MMP9 PTGS2 NFKB1 CASP3 IL6 IL1B SOD1 GPX1 HMOX1 TGFB1 ACTA2 CYP2E1 BAX TIMP1 GSTP1 CTGF

Chemical Liver Injury STAT3 MMP2 TNF MAPK8 PPARG NFKB1 IL1B SOD1 GPX1 HMOX1 TGFB1 ACTA2 CYP2E1 TIMP1 GSTP1

Drug-induced Liver Injury BCL2 NFE2L2 TNF NOS2 MAPK8 PTGS2 NFKB1 CASP3 IL6 SOD1 GPX1 HMOX1 CYP2E1 BAX GSTP1

Inflammation STAT3 ALOX5 TNF NOS2 MAPK8 PPARG MMP9 PTGS2 NFKB1 IL6 IL1B HMOX1 CXCL8 PTGER2

Product description Related Products Prediction Parameters Reference Literature

Synonym name: Giganteaside J; Giganteoside J
Catalogue No.: BP0908
Cas No.: 140360-29-8
Formula: C₅₉H₉₆O₂₇
Mol Weight: 1237.39
Botanical Source: Dipsacus asper, Aralia elata, Cephalaria gigantea and Lonicera macranthoides

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.

Description:

Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.

References:

Journal of Chromatography B Volume 877, Issue 3, 15 January 2009, Pages 159–165

Liquid chromatography–mass spectrometry analysis of macranthoidin B, macranthoidin A, dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation

METHODS AND RESULTS:

A liquid chromatography-electrospray ionization–mass spectrometry method has been developed and validated for identification and quantification of four major bioactive saponins in rat plasma after oral administration of extraction of saponins from Flos Lonicerae, i.e., macranthoidin B, Macranthoidin A, dipsacoside B, and macranthoside B. Plasma samples were extracted with solid-phase extraction, separated on a Shim-pack CLC-ODS column and detected by MS in negative selective ion monitoring mode. Calibration curves offered linear ranges of two orders of magnitude with r2 > 0.999. The method showed the low limit quantification of 7.72, 6.06, 7.16, and 1.43 ng/mL for macranthoidin B, Macranthoidin A, dipsacoside B, and macranthoside B, respectively. The inter- and intra-CV precision (R.S.D.) were all within 10% and accuracy (% bias) ranged from −10 to 10%. The overall recovery was more than 70%.

CONCLUSIONS:

This developed method was subsequently successfully applied to pharmacokinetic profiles of the four saponins in rats. After oral administration of extraction of saponins in rats, the concentration–time course was found to be the double peaks of curve.

HPLC of Macranthoidin A