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Synonym name:
Catalogue No.: BP0457
Cas No.: 14259-55-3
Formula: C16H22O11
Mol Weight: 390.341
Botanical Source: Rubia peregrina and Rubia tinctorum
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Description:
Deacetylasperulosidic acid inhibits the reduction of ear swelling, and also cancels the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext. Deacetylasperulosidic acid may increase catalase activity.
References:
Nat Prod Commun. 2014 Apr;9(4):445-50.
Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents.
Morinda citrifolia, commonly known as noni, is a traditional natural medicine in French Polynesia and Hawaii. Functional foods derived from M. citrifolia fruit have been marketed to help prevent diseases and promote good health.
METHODS AND RESULTS:
The objective of this study was to assess the effects of M. citrifolia fruit on cell-mediated immunity. In the picryl chloride-induced contact dermatitis test, M. citrifolia fruit extract (Noni-ext) inhibited the suppression of cell-mediated immunity by immunosuppressive substances isolated from freeze-dried ascites of Ehrlich carcinoma-bearing mice (EC-sup). In addition, Noni-ext inhibited reduction of IL-2 production in EC-sup-treated mice and activated natural killer cells in normal mice.
CONCLUSIONS:
These results suggest that Noni-ext has multiple effects on the recovery of cell-mediated immunity. Furthermore, we investigated the active principles of Noni-ext and identified an iridoid glycoside, Deacetylasperulosidic acid. Oral administration of Deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext.
HPLC of Deacetylasperulosidic acid
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
186.3700
-1.7182
-3.4524
55.1060
.4556
.3693
Low
31.3245
4.8283
Yes
No
No
No
No
No
0.0
Yes
Yes
Yes
Yes
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