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Product name: Taxifolin
Synonym name: (+)-Dihydroquercetin;(+)-Taxifolin; (+)-trans-Taxifolin;Distylin
Catalogue No.: BP1367
Cas No.: 480-18-2
Formula: C15H12O7
Mol Weight: 304.254
Botanical Source: Polygoni Orientalis Fructus
Physical Description:
Type of Compound: Flavonoids
Purity: 80%,90%,95%,98%
Analysis Method: HPLC-DAD
Identification Method: Mass, NMR
Packing: As per customer requirements
The product could be supplied from milligrams to grams, up to kilogram.
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
HPLC of Taxifolin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
127.4500
1.0495
.8207
.8136
1.6021
.4215
Low
74.0185
3.3609
Yes
No
Yes
No
Yes
No
1.2
Yes
No
Yes
No
Taxifolin, also known as (+)-dihydroquercetin, is a natural flavonoid compound widely found in various plants, possessing significant biological activity and pharmacological potential. As an important natural product, Scottifolin has attracted widespread attention in the field of natural drug development in recent years due to its outstanding antioxidant, anti-fibrotic, and antityrosinase activities. Its potential applications in anti-aging, anti-inflammation, anti-tumor, and neuroprotective areas have made it a hot topic in pharmacological research. This paper systematically reviews the chemical structure and physicochemical properties of Turpetalin, plant origin and extraction methods, pharmacological activity and mechanism of action, druggability evaluation, and clinical application prospects, aiming to provide theoretical basis and research directions for the pharmacology of natural products and related drug development.
The chemical name of tuftisin is (+)-dihydroquercetin, molecular formula C15H12O7, molecular weight 304.2540, CAS number 480-18-2. Its structure belongs to the flavonoid category of dihydroflavonoids (flavanonol), featuring a typical tricyclic structure (C6-C3-C6), which includes two benzene rings (A and B rings) and one oxygen heterocycle (C ring). Compared to quercetin, dosiethine is saturated at the C2-C3 positions and lacks double bonds, giving it greater stability and unique biological activity.
In terms of physicochemical properties, the LogP value of tuftisterin is 1.0495, indicating moderate lipid solubility, which facilitates cell membrane penetration. The topological polar surface area (TPSA) was 127.45 Ų, indicating high polarity and moderate water solubility (0.8136), which significantly affects bioavailability and distribution in vivo. The blood-brain barrier has low permeability, suggesting its direct role in the central nervous system is limited. The hERG channel inhibition test was negative, indicating a low risk of cardiotoxicity. The Ames test result was 1.2, indicating a low genotoxicity risk and a solid safety foundation.
Douglas is widely found in various plants, especially abundant in pines (such as Pinus strobus), grapes (Vitis vinifera), onions (Allium cepa), and citrus fruits. Its natural form is mainly in free or glycoside bonded form, and different plant sources and growth environments significantly affect its content.
The extraction methods mainly include solvent extraction, ultrasound-assisted extraction, microwave-assisted extraction, and membrane separation technology. Traditional solvent extraction mostly uses ethanol, water, or their mixed solvents, with extraction efficiency greatly affected by temperature, time, and solvent polarity. Ultrasound-assisted extraction, due to its high efficiency and energy savings, has become one of the mainstream technologies, significantly improving the extraction rate of tuftison and shortening the time. In recent years, green extraction technologies such as supercritical CO2 extraction and enzyme-assisted extraction have gradually been applied to the extraction of dosifolin, improving purity and the stability of active ingredients.
After extraction, techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) are commonly used for purity identification and structural confirmation to ensure product quality and research accuracy.
As a natural free radical scavenger, Turpetalin has significant antioxidant properties. The hydroxyl groups in its molecular structure can effectively capture reactive oxygen species (ROS) and free radicals, reducing cellular damage caused by oxidative stress. Multiple in vitro and in vivo studies have shown that thylosin can enhance the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD1) and catalase (CAT), activate the nuclear factor E2-related factor 2 (NRF2) signaling pathway, and promote antioxidant gene expression, thereby protecting cells from oxidative damage.
Tyrosine has an important inhibitory effect on tyrosinase, a key enzyme for melanin synthesis. Inhibiting its activity helps with whitening and preventing pigmentation. Additionally, tuftinocortin effectively inhibits collagenase, with an IC50 of 193.3 μM, which can slow down collagen degradation, protect skin structure integrity, and delay skin aging.
Fibrosis is the pathological basis for various chronic diseases such as liver fibrosis, pulmonary fibrosis, and renal fibrosis. Turpetalin slows tissue fibrosis by inhibiting fibroblast activation and collagen deposition. Its mechanism of action involves regulating the transforming growth factor β (TGF-β) signaling pathway, inhibiting the expression of fibrosis-related genes, reducing inflammatory responses and oxidative stress, and demonstrating strong anti-fibrotic potential.
Research on the anti-aging field of thyrsisin is becoming increasingly in-depth. By activating key targets such as 5' AMP-activated protein kinase (AMPK), silencing information regulatory factor 1 (SIRT1), and telomerase reverse transcriptase (TERT), it regulates cellular energy metabolism, delays telomere shortening, promotes autophagy, and delays cellular aging. Meanwhile, dodosilon regulates the tumor suppressor gene TP53, cell cycle regulator CDKN1A, and transcription factor FOXO1, promoting the maintenance of cell homeostasis. Additionally, it induces the expression of the antioxidant enzyme HMOX1, enhancing cells' resistance to oxidative damage and providing comprehensive anti-aging effects.
In addition to the above effects, turpetalin also exhibits various pharmacological activities, including anti-inflammatory, anti-tumor, neuroprotection, and cardiovascular protection. In the inflammation model, tusifolin reduces inflammatory factor release and tissue damage by inhibiting the NF-κB signaling pathway. It exhibits proliferation inhibition and apoptosis induction effects on various tumor cells, demonstrating potential anticancer value. In terms of neuroprotection, dodophorin protects nerve cell survival and improves cognitive function by reducing oxidative stress and inflammatory responses.
The multi-target mechanism of tuftisone forms the basis of its broad pharmacological activity. Its main targets and signaling pathways include:
Overall, through multi-target and multi-pathway synergistic effects, Cytotaxidon regulates cellular metabolism, antioxidant properties, and prevents apoptosis and fibrosis, demonstrating broad biological effects.
The druggability parameters of petalsolin indicate that it has promising potential for drug development. Molecular weight 304.2540 complies with the Lipinski rule, which is beneficial for oral absorption. A moderate LogP value (1.0495) indicates moderate lipid solubility, which is beneficial for distribution in the body. The high TPSA value of 127.45 suggests strong polarity, which may limit cell membrane penetration and oral absorption, but also helps balance water solubility and bioavailability. Water solubility of 0.8136, supporting its dissolution and delivery in the body.
The low permeability of the blood-brain barrier limits its direct effects on the central nervous system, but also reduces the risk of potential CN toxicity. hERG channel inhibition negative, reducing the risk of cardiotoxicity. Ames test results showed low genotoxicity risk and good safety.
Pharmacokinetic studies show that petalquinine is absorbed orally relatively quickly, has a moderate plasma half-life, and is mainly metabolized by the liver, with most metabolites being sulfate and glucuronide conjugates. Its bioavailability is limited by first-pass effects and intestinal metabolism, and the development of novel delivery systems such as nanocarriers and liposomes is expected to improve its pharmacokinetic properties.
With its multiple pharmacological activities, especially its potential in antioxidant, anti-fibrotic, and anti-aging fields, Tusifolin has broad clinical application prospects. In dermatology, tusistanin is used as a tyrosinase and collagenase inhibitor and can be developed as a whitening and anti-aging skincare product and a drug for treating pigmentation. In liver and pulmonary fibrosis diseases, Tuijizine is expected to become an adjunctive therapy by inhibiting the process of fibrosis.
Additionally, the protective effects of tuftisone in neurodegenerative diseases, cardiovascular diseases, and metabolic syndromes have made it a candidate for multi-target therapy. In the future, combining modern drug delivery technologies with structural modification is expected to enhance bioavailability and targeting, driving clinical translation.
However, clinical research on tuxisone is still limited, and systematic clinical trials are urgently needed to verify its safety and efficacy. At the same time, in-depth analysis of its mechanisms of action and metabolic pathways will provide scientific evidence for drug development.
As an important natural flavonoid compound, dodosilin demonstrates broad pharmacological potential and good druggability due to its excellent antioxidant, anti-fibrotic, and anti-aging activities. Its multi-target and multi-pathway mechanisms offer new ideas for the prevention and treatment of various chronic diseases. In the future, combining modern medicinal chemistry and drug delivery technologies, tusitaxine is expected to become an important candidate for natural product drug development. Systematic clinical research and mechanism exploration will be key to advancing its clinical application. In summary, tuxisal has significant research value and application prospects in the field of natural product pharmacology.
Shenshuai
Wenjing
Hedandan
