Isoquercitrin

Name: Isoquercitrin
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0793

CAS NO.: 482-35-9

Purity: 98%

Brand: Phytopurify

Botanical Source:

Isoquercitrin has anti-tumoral, antihypertensive, anti-osteoporosis, anti-allergy, anti-inflammatory, and antiasthmatic activities, it also may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. Isoquercitrin is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation; it is also a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. Isoquercitrin inhibited carbachol and leukotriene D4 -induced contraction in guinea-pig airways, and it induced hypotension in rats is an event dependent on the inhibition of angiotensin II generation by angiotensin converting enzyme (ACE). Quercetin 3-O-beta-D-glucopyranoside is a quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells.

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BP0793-20mg	20mg	Sign in	Sign in
BP0793-100mg	100mg	Sign in	Sign in
BP0793-500mg	500mg	Sign in	Sign in
BP0793-1000mg	1000mg	Sign in	Sign in

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Antioxidant damage NRF2 SOD1 CAT GPX1 HMOX1

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Synonym name: Isoquercitin; Quercetin 3-glucoside; Hirsutrin; Isoquercitroside ; Isoquercetin

Catalogue No.: BP0793
Cas No.: 482-35-9
Formula: C₂₁H₂₀O₁₂
Mol Weight: 464.379
Botanical Source: Occurs widely in plants

Purity: 98%
Analysis Method: HPLC-DAD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams, up to Kgs.

Available for R&D, food, nutrition and cosmetics.

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The flavonoid isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with α-l-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver. Biotransformation of isoquercitrin includes deglycosylation, followed by formation of conjugated and methylated derivatives of quercetin or degradation to phenolic acids and carbon dioxide. The acceptable daily intake of (95%) isoquercitrin and of EMIQ was estimated to be 5.4 and 4.9 mg/kg/day, respectively. Adverse effects of higher doses in rats included mostly (benign) chromaturia; nevertheless some drug interactions may occur due to the modulation of the activity and/or expression of drug metabolizing/transporting systems. With respect to the safety, affordability and beneficial pharmacological activities, highly pure isoquercitrin is a prospective substance for food supplementation.

HPLC of Isoquercitrin