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Product name: Ginsenoside Rd
Synonym name: Gypenoside VIII
Catalogue No.: BP0661
Cas No.: 52705-93-8
Formula: C48H82O18
Mol Weight: 947.166
Botanical Source: Panax ginseng (ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside Rd (Rd), a saponin isolated from the roots of panax notoginseng, Rd has immunological adjuvant activity, and elicits a Th1 and Th2 immune response by regulating production and gene expression of Th1 cytokines and Th2 cytokines.[1]
Ginsenoside-Rd could play a crucial role in enhancing the defence system to counteract the aging process, through regulation of the GSH/GSSG redox status, decreasing in the superoxide dismutase (SOD) and catalase activity in old SAM.[2]
Ginsenoside-Rd treatment shows attenuation of hypertensive cerebrovascular remodeling, the underlying mechanism might be associated with inhibitory effects of ginsenoside-Rd on voltage-independent Ca 2+ entry and BAVSMC proliferation, but not with VDCC-mediated Ca 2+ entry.[3]
Ginsenoside Rd, a -type steroid extracted from , has exhibited an encouraging neuroprotective efficacy in both laboratory and clinical studies, could be as a neuroprotective agent for acute .[4]
Ginsenoside Rd can enhance the proliferation but not affect the differentiation of neural stem cells in vivo and in vitro.[5]
Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons and may be the potential of voltage-independent Cachannel blockers as new neuroprotective drugs for the prevention of neuronal apoptosis and death induced by cerebral ischaemia.[6]
References:
[1] Yang Z, Chen A, Sun H, et al. Vaccine, 2007, 25(1):161-9.
[2] Takako Y, Akiko S, Ju C E. J Pharma Pharmacol, 2004, 56(1):107-13.
[3] Cai B X, Li X Y, Chen J H, et al. Eur J Pharmacol, 2009, 606(1–3):142-9.
[4] Ye R, Gang Z, Liu X. Expert Rev Neuroth, 2013, 13(6):603-13.
[5] Lin T, Liu Y, Shi M, et al. J Ethnopharmacol, 2012, 142(3):754–61.
[6] Li X Y, Liang J, Tang Y B, et al. Clin Exp Pharmacol P , 2010, 37(2):199–204.
[7] Qin H Y, Suo Z R, Wei Y Q. Journal of Southwest University of Science & Technology, 2013, 28(02):92-94.
HPLC of Ginsenoside Rd
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
298.1400
2.4782
2.4780
.1105
.4896
.1440
Low
71.4485
6.3768
No
No
No
No
No
No
0.0
Yes
No
No
No
Shenshuai
Wenjing
Hedandan
