Geniposidic acid

Name: Geniposidic acid
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0633

CAS NO.: 27741-01-1

Purity: 98%

Brand: Phytopurify

Botanical Source: Gardenia jasminoides Ellis

Geniposidic acid is an effective anticancer and radioprotection agent, used to treat inflammation, jaundice and hepatic disorders. It has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model. Geniposidic acid has effects on the expression of MRP2 and BSEP in BRL-3A cells after FXR gene silencing mediated by si RNA.

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BP0633-20mg	20mg	Sign in	Sign in
BP0633-100mg	100mg	Sign in	Sign in
BP0633-1000mg	1000mg	Sign in	Sign in

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Related diseases

Inflammatory Bowel Disease Type 2 Diabetes Mellitus Colon cancer Drug-induced Liver Injury Metabolic Dysfunction-Associated Steatotic Liver Disease

Related targets

Inflammatory Bowel Disease TLR4 NFE2L2 TNF PPARG NFKB1 IL6 HMOX1 PPARA OCLN

Type 2 Diabetes Mellitus TLR4 NFE2L2 NR1H4 TNF PPARG SREBF1 NFKB1 IL6 HMOX1 IRS1 SLC2A4 PPARA GLP1R

Colon cancer BCL2 NFE2L2 TNF PPARG TP53 NFKB1 CASP3 CTNNB1 KRAS CDH1 APC

Drug-induced Liver Injury BCL2 NFE2L2 TNF TP53 NFKB1 CASP3 IL6 HMOX1 CYP2E1

Metabolic Dysfunction-Associated Steatotic Liver Disease NR1H4 TNF PPARG SREBF1 IL6 CYP7A1 PPARA

Product description Related Products Prediction Parameters Reference Literature

Product name: Geniposidic acid
Synonym name: Premnosidic acid
Catalogue No.: BP0633
Cas No.: 27741-01-1
Formula: C₁₆H₂₂O₁₀
Mol Weight: 374.342
Botanical Source: Genipa americana (genipap), Garrya elliptica and Premna barbata
Physical Description: Powder
Type of Compound: Iridoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Geniposidic acid, one of the main active ingredients in Gardenia jasminoides J. Ellis (Rubiaceae), has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model.[1]
Geniposidic acid and geniposide have antitumor effects , play a role in an effective anticancer product with the ability to decrease undesirable radiation damage to the hematologic tissue after high dose irradiation.[2]
Geniposidic acid can protect against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.[3]
Geniposidic acid protects against anti-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.[4]
Geniposidic acid has effects on the expression of MRP2 and BSEP in BRL-3A cells after FXR gene silencing mediated by si RNA.[5]

References:
[1] Yu G, Zi-Yu C, Xue L, et al. Pharm Biol, 2014, 53(2):1-6.
[2] Hsu H Y, Yang J J, Lin S Y, et al. Cancer Lett, 1997, 113(1-2):31-7.
[3] Kim S J, Kim K M, Park J, et al. J Ethnopharmacol, 2013, 146(1):271-7.
[4] Chen H, Huang X, Min J, et al. J Ethnopharmacol 2015, 179:197-207.
[5] Chen H, Shi S, Min J B, et al.China Journal of Traditional Chinese Medicine & Pharmacy, 2016,5.
[6] Peng M J, Zhang M, Liu J L, et al. Chinese Journal of Hospital Pharmacy, 2005, 25(04):300-2.