Ellagic Acid

Name: Ellagic Acid
Brand: Biopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0529

CAS NO.: 476-66-4

Purity: 98%

Brand: Biopurify

Botanical Source: Galla chinensis

Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. It has a role as an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor, a geroprotector, an antioxidant, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5. Ellagic acid is a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Ellagic acid has anti-inflammatory, antiproliferative and antioxidant properties, it can prevent cognitive and LTP deficits and also prevent brain inflammation following TBI. Ellagic acid reduced the expression of NO, MDA, IL-1β, TNF-α, COX-2 and NF-κB, and induced the production of GSH and IL-10.

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Related diseases

Alzheimer's Disease Breast cancer Prostate cancer Colon cancer Hepatocellular Carcinoma

Related targets

Alzheimer's Disease BACE1 BCL2 STAT3 NFE2L2 CASP1 RELA TNF CYP19A1 NOS2 GSK3B ACHE PIK3CA MMP9 PTGS2 CASP3 CTNNB1 MTOR

Breast cancer BCL2 STAT3 NFE2L2 RELA CYP19A1 AR PIK3CA MMP9 PTGS2 TP53 CDK2 CASP3 CTNNB1 CDH1 MTOR KDR

Prostate cancer BCL2 STAT3 NFE2L2 CASP1 RELA TNF CYP19A1 AR PIK3CA MMP9 PTGS2 TP53 CDK2 CASP3 CTNNB1 MTOR KDR

Colon cancer BCL2 STAT3 NFE2L2 RELA TNF NOS2 GSK3B PIK3CA MMP9 PTGS2 TP53 CDK2 CASP3 CTNNB1 KRAS CDH1 APC MTOR KDR

Hepatocellular Carcinoma BCL2 STAT3 NFE2L2 RELA TNF NOS2 AR GSK3B PIK3CA MMP9 PTGS2 TP53 CDK2 CASP3 CTNNB1 KRAS CDH1 MTOR KDR

Product description Related Products Prediction Parameters Reference Literature

Product name: Ellagic Acid
Synonym name: Benzoaric acid; Elagostasine; Lagistase
Catalogue No.: BP0529
Cas No.: 476-66-4
Formula: C₁₄H₆O₈
Mol Weight: 302.194
Botanical Source: Widely distributed in higher plants; found by Bate-Smith in 75 genera of dicotyledons and in only one monocotyledonous sp., Hypoxis filiformis
Physical Description: Powder
Type of Compound: Phenols

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100, is due to specific inhibition of methylation at the O6 position of guanine through an ellagic acid-duplex DNA affinity-binding mechanism.[1]
Ellagic acid has anti-oxidant and anti-inflammatory properties, can inhibit key cell functions and activation of PSCs, including platelet-derived growth factor (PDGF)-BB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, alpha-smooth muscle actin and collagen genes. [2]
Ellagic acid has antioxidant and apoptosis-inducing activities, shows high DPPH radical scavenging and peroxidation inhibition activities, significantly reduces HOS cell proliferation, and induces apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance.[3]

References:
[1] Dixit R, Gold B. P Natl Acad Sci USA, 1986, 83(21):8039-43.
[2] Masamune A, Satoh M, Kikuta K, et al. Biochem Pharmacol, 2005, 70(6):869-78.
[3] Han D H, Lee M J, Kim J H. Anticancer Res, 2006, 26(5A):3601-6.
[4] Ou L M, Seken A, Li K A, et al. Int J Pharm Res, 2015, 42(05):637-41.