Amygdalin

Catalogue No.： BP0162

CAS NO.: 29883-15-6

Purity: 98%

Brand: Biopurify

Botanical Source: Tagetes erecta L

Amygdalin is an amygdalin in which the stereocentre on the cyanohydrin function has R-configuration. It has a role as an antineoplastic agent, an apoptosis inducer and a plant metabolite. It is functionally related to a (R)-mandelonitrile. Amygdalin has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of Amygdalin or HSYA. Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax. Amygdalin is a plant glucoside isolated from the nucleus of rose fruits, such as apricots, peaches, almonds, cherries, and plums.

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Related diseases

Subarachnoid Hemorrhage Breast cancer Liver fibrosis Prostate cancer Intervertebral Disc Degeneration

Related targets

Subarachnoid Hemorrhage STAT3 CLEC4E EPHX2 LGALS3 FGF1

Breast cancer BCL2 STAT3 MMP2 RELA CASP9 AR PTGS2 CASP3 VEGFA BAX CDKN1A PARP1

Liver fibrosis BCL2 STAT3 MMP2 RELA TNF NOS2 PTGS2 CASP3 IL1B TGFB1 ACTA2 VEGFA COL1A1 BAX

Prostate cancer BCL2 STAT3 MMP2 RELA CASP9 TNF AR LGALS3 PTGS2 CASP3 VEGFA BAX CDKN1A PARP1

Intervertebral Disc Degeneration TNF NOS2 PTGS2 IL1B MMP3 ACAN

Product description Related Products Prediction Parameters Reference Literature

Product name: Amygdalin
Synonym name: Amygdaloside; Mandelonitrile gentiobioside; Glucoprunasin; Laetrile; Vitamin B17
Catalogue No.: BP0162
Cas No.: 29883-15-6
Formula: C₂₀H₂₇NO₁₁
Mol Weight: 457.432
Botanical Source: Bitter glycoside of the Rosaceae, found esp. in kernels of cherries, peaches and apricots. Present in cold pressed bitter almond oil from the above sources prior to enzymic hydrolysis and steam distillation for food use
Physical Description: Powder
Type of Compound: Phenols

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax,suggests it may offer a valuable option for the treatment of prostate cancers.[1]
Amygdalin suppresses the prostaglandin E(2) synthesis and the nitric oxide production by inhibiting the LPS-stimulated mRNA expressions of COX-2 and iNOS in the mouse BV2 cells.[2]
Amygdalin can inhibit genes related to cell cycle in SNU-C4 human colon cancer cells.[3]

References:
[1] Chang H K, Shin M S, Yang H Y, et al. Biol Pharm Bull, 2006, 29(8):1597-602.
[2] Yang H Y, Chang H K, Lee J W, et al. Neurol Res, 2013, 29 suppl 1(1):59-64(6).
[3] Park H J, Yoon S H, Han L S, et al. World J Gastroentero, 2005, 11(33):5156-61.
[4] Zhou C, Chen K, Sun C, et al. Biomed Chromatogr, 2007, 21(7):755-61.