1,2,3,4,6-Pentagalloylglucose

Name: 1,2,3,4,6-Pentagalloylglucose
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP0001

CAS NO.: 14937-32-7

Purity: 98%

Brand: Phytopurify

Botanical Source: Galla chinensis

1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose is a galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions. It has a role as a geroprotector, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a galloyl beta-D-glucose and a gallate ester. It is a conjugate acid of a 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose(1-).

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Related diseases

Hyperglycemia Acute Lymphoblastic Leukemia Atherosclerosis Alzheimer's Disease Non-alcoholic fatty liver disease

Related targets

Hyperglycemia APP SGLT2 BACE1 GCK EHMT2 UBP2 AMPK PAI1 NFE2L2 NOS2 GSK3B SREBF1

Acute Lymphoblastic Leukemia NOTCH1 BCL2 BLM UBP2 MCL1 NFE2L2 RELA CASP3

Atherosclerosis ABCA1 RECQ1 BCL2 LOX-1 EHMT2 AMPK MCL1 NFE2L2 RELA TNF NOS2 SREBF1 PTGS2 CASP3 IL6 BDNF PPARA

Alzheimer's Disease APP NOTCH1 ABCA1 BACE1 BCL2 AMPK MCL1 MAPT NFE2L2 RELA TNF NOS2 GSK3B ACHE PTGS2 CASP3 IL6 BDNF

Non-alcoholic fatty liver disease AMPK NFE2L2 RELA TNF NOS2 ACHE SREBF1 PTGS2 CASP3 IL6 TGFB1 ACTA2 CYP2E1 PPARA

Product description Related Products Prediction Parameters Reference Literature

Synonym name: Beta-1,2,3,4,6-Pentagalloylglucose
Catalogue No.: BP0001
Cas No.: 14937-32-7
Formula: C₄₁H₃₂O₂₆
Mol Weight: 940.681
Botanical Source: several Acer spp., Quercus spp., Rhus spp. and Rubus spp.

Purity: 99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams, up to kilograms.

Except the reference standerd, we can supply this product with 80%~95% for food supplements, health care products, cosmetics etc.
Inquire for bulk scale.

References

1, Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose
Pharmaceutical Research September 2009, Volume 26, Issue 9, pp 2066-2080

Abstract

1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG) is a polyphenolic compound highly enriched in a number of medicinal herbals. Several in vitro and a handful of in vivo studies have shown that PGG exhibits multiple biological activities which implicate a great potential for PGG in the therapy and prevention of several major diseases including cancer and diabetes. Chemically and functionally, PGG appears to be distinct from its constituent gallic acid or tea polyphenols. For anti-cancer activity, three published in vivo preclinical cancer model studies with PGG support promising efficacy to selectively inhibit malignancy without host toxicity. Potential mechanisms include anti-angiogenesis; anti-proliferative actions through inhibition of DNA replicative synthesis, S-phase arrest, and G₁arrest; induction of apoptosis; anti-inflammation; and anti-oxidation. Putative molecular targets include p53, Stat3, Cox-2, VEGFR1, AP-1, SP-1, Nrf-2, and MMP-9. For anti-diabetic activity, PGG and analogues appear to improve glucose uptake. However, very little is known about the absorption, pharmacokinetics, and metabolism of PGG, or its toxicity profile. The lack of a large quantity of highly pure PGG has been a bottleneck limiting in vivo validation of cancer preventive and therapeutic efficacies in clinically relevant models.