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Product name: Curcumol
Synonym name: 5,8-Epoxy-10(14)-guaien-8-ol
Catalogue No.: BP0422
Cas No.: 4871-97-0
Formula: C15H24O2
Mol Weight: 236.355
Botanical Source: Curcumae Rhizoma
Physical Description:
Type of Compound: Sesquiterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
HPLC of Curcumol
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
40.4600
2.8000
2.5000
High
No
No
No
No
No
No
No
Curcumol, CAS number 4871-97-0, is a naturally occurring sesquiterpene compound, mainly distributed in the ginger family plant Curcuma (Curcuma wenyujin Y.H. Chen et C. Ling). As a natural compound with multiple biological activities, curcuma alcohol demonstrates significant pharmacological potential in anticancer, antimicrobial, antifungal, antiviral, and anti-inflammatory fields. In recent years, with advances in natural product pharmacology and molecular biology technologies, the mechanism of action and its molecular targets of curvachu alcohol have gradually been revealed. In particular, it has become an important candidate molecule for anti-tumor drug development by regulating key cellular signaling pathways to induce apoptosis in various tumor cells.
This review aims to systematically summarize the chemical structure and physicochemical properties of curcuma alcohol, plant origin and extraction methods, progress in pharmacological activity research, mechanisms of action and molecular targets, druggability evaluation, and pharmacokinetic characteristics, as well as explore its clinical application prospects and future research directions, providing theoretical support and reference for researchers in related fields.
Curcumazol is a sesquiterpene compound with a molecular formula C_15H_24O_2 and a molecular weight of 236.35. Its chemical structure includes a typical sesquiterpene skeleton, with two hydroxyl groups, giving it certain polarity and biological activity. The LogP value of curdron alcohol is 2.8, indicating moderate lipid solubility, which facilitates cell membrane penetration and distribution in vivo. The topological pole surface area (TPSA) is 40.46 Ų, and the number of hydrogen bond receptors is 2, indicating that it possesses certain hydrogen bond formation capability in drug binding to target proteins.
Curcurlotol has high blood-brain barrier permeability, indicating its potential to act on central nervous system-related diseases. Additionally, curcuma alcohol demonstrated good safety in vivo, with no hepatotoxicity, cardiotoxicity, or hERG channel inhibition, and the Ames-inducing mutagenic test was negative, indicating a low genotoxicity risk.
Curcuma (Curcuma wenyujin) is mainly found in the ginger family plant Curcuma wenyujin, which is widely used in traditional Chinese medicine for promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain. As an important component of curcuma zedoary volatile oil and fat-soluble components, its content and quality are significantly influenced by the planting environment, harvest time, and processing methods.
Traditional extraction methods mostly use solvent extraction combined with fractionation technology. Common extraction solvents include ethanol, methanol, ethyl acetate, etc., which are purified by column chromatography and liquid chromatography preparation after extraction. In recent years, green and efficient technologies such as ultrasound-assisted extraction and microwave-assisted extraction have been introduced into the extraction process of curcurd, significantly improving extraction efficiency and purity, while reducing the use of organic solvents, in line with modern green chemistry concepts.
Pharmacological research on curcurvachil covers anti-tumor, antimicrobial, antifungal, antiviral, and anti-inflammatory aspects.
Curstanol exhibits significant inhibitory effects across various tumor cell lines, especially in solid tumors such as breast, lung, liver, and colorectal cancers. Its anti-cancer mechanism mainly operates through multiple pathways, including inducing apoptosis, inhibiting cell proliferation, blocking the cell cycle, and suppressing tumor cell migration and invasion.
In breast cancer, curcurlotol can regulate various key molecular targets such as AMPK (PRKAA1), BCL2, STAT3, ESR2, ABCB1, ABCG2, PRKCA, MAPT, NFE2L2, and TOP1, significantly inhibiting tumor cell growth and drug resistance. By activating the AMPK signaling pathway, it inhibits BCL2-mediated anti-apoptotic mechanisms, reduces the cancer-promoting transcriptional activity of STAT3, and enhances cell apoptosis signaling.
Curcurbutol exhibits inhibitory effects on various pathogenic bacteria and fungi, especially showing strong bactericidal activity against Gram-positive bacteria and certain fungal strains. Its mechanism of action may involve disrupting cell membrane structure, inhibiting key enzyme activities, and interfering with microbial metabolic processes.
Curcurdrol exhibits inhibitory effects on various viruses, including influenza virus and hepatitis B virus. Research shows that curcuma alcohol can exert antiviral effects by regulating the host cell's immune response and directly inhibiting viral replication.
Curcurlotol significantly alleviates inflammatory responses by inhibiting the NF-κB signaling pathway, reducing the expression of pro-inflammatory factors such as TNF-α, IL-6, and IL-1β. Its anti-inflammatory effects have been validated in various inflammatory models, demonstrating its potential application value in treating inflammatory diseases.
The multi-target mechanism of curcurlotol forms the basis of its broad pharmacological activity. It mainly regulates key intracellular signaling pathways, including MAPK/ERK, PI3K/Akt, and NF-κB, thereby modulating cell proliferation, apoptosis, and inflammatory responses.
In cancer treatment, curvachu alcohol promotes energy metabolism regulation by activating the AMPK (PRKAA1) pathway, inhibiting tumor cell growth. Its regulation of BCL2 family proteins reduces anti-apoptotic signaling and promotes mitochondrial pathway-mediated apoptosis. When the STAT3 signaling pathway is inhibited, tumor cell proliferation and immune escape ability are weakened. Curcurazol also affects the expression of ABCB1 and ABCG2 in drug efflux pumps, overcoming multidrug resistance in tumor cells.
Additionally, curterol regulates the estrogen receptor ESR2, affecting the growth of hormone-dependent tumors. PRKCA and MAPT, as key proteins for cell signal transduction and microtubule stability, are also regulated by curvachuol, further affecting cell cycle and migration capacity. NFE2L2, as a regulator of oxidative stress responses, helps cells resist oxidative damage by regulating its activity. TOP1, as a DNA topoisomerase, helps block DNA replication and transcription in tumor cells.
Curturdyl alcohol has good druggability parameters. Its molecular weight is 236.35, moderate lipid solubility (LogP 2.8), and low polarity (TPSA 40.46) facilitates oral absorption and cell membrane penetration. The number of hydrogen bond receptors is 2, which complies with the Lipinski rule and facilitates binding to target proteins.
The high permeability of the blood-brain barrier suggests that quercelitol has potential advantages in treating central nervous system diseases. Toxicological evaluations showed that curcumulol had no significant hepatotoxicity, cardiotoxicity, or hERG channel inhibition, and was relatively safe. A negative Ames test indicates a low genotoxicity risk and is suitable for further drug development.
Pharmacokinetic studies show that curvachu alcohol has good bioavailability and distribution in the body, with metabolic pathways mainly involving hepatic enzyme systems and excretion primarily via bile and urine. Its moderate half-life allows it to maintain effective plasma concentrations and supports the design of clinical dosing regimens.
As a multifunctional natural product, Curcuma alcohol possesses broad pharmacological activity and good safety, demonstrating strong clinical application potential. Especially in adjuvant therapy for solid tumors such as breast cancer, curstanol regulates tumor cell proliferation and apoptosis through multiple targets and pathways, showing promise to overcome the resistance and side effects of traditional chemotherapy drugs.
Future research should focus on preclinical efficacy evaluation, formulation optimization, and combination therapy strategies for curcuminol, further clarifying its pharmacokinetic characteristics and safety evaluation. At the same time, based on modern molecular pharmacology techniques, the interaction mechanisms between curturdyl alcohol and target proteins are deeply analyzed to promote clinical translation.
In addition, the potential applications of curcurvacyl alcohol in anti-inflammatory, antiviral, and neuroprotective fields are also worth attention. By combining nanotechnology with targeted delivery systems, its bioavailability and targeting are expected to improve, expanding its clinical application scope.
As a natural sesquiterpene with multiple pharmacological activities, the unique chemical structure and excellent druggability of curcumazol show broad clinical application prospects. Its remarkable activity in anticancer, antimicrobial, antiviral, and anti-inflammatory areas provides valuable resources and ideas for the development of natural product drugs. In the future, through systematic pharmacological mechanism research and preclinical evaluation, Curturel is expected to become an important representative of new natural medicines, promoting the application and development of natural products in modern medicine.
Shenshuai
Wenjing
Hedandan
