Asiatic acid

Catalogue No.： BP0203

CAS NO.: 464-92-6

Purity: 98%

Brand: Phytopurify

Botanical Source:

Asiatic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity. It has a role as a metabolite and an angiogenesis modulating agent. It is a monocarboxylic acid, a pentacyclic triterpenoid and a triol. It is a conjugate acid of an asiatate. It derives from a hydride of an ursane. Asiatic acid shows antihyperlipidemic, anti-inflammatory, antioxidant, and anti-tumorigenesis effects, it inhibits NLRP3 inflammasome activation, NO and COX-2 signals. Asiatic acid inhibits the expression NDR1/2 kinase and promotes the stability of p21WAF1/CIP1 protein through attenuating NDR1/2 dependent phosphorylation of p21WAF1/CIP1 in HepG2 cells. Asiatic acid， It is a pentacyclic triterpenoid found in Centella asiatica, which has anti-cancer activity. Asiatic acid can induce apoptosis in melanoma cells and has a barrier protective effect on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and can inhibit endothelial barrier dysfunction induced by tumor necrosis factor (TNF) - α. Asiatic acid also inhibits NLRP3 inflammasome activation and NF - κ B pathway, effectively suppressing inflammation in rats, and has neuroprotective effects in a rat spinal cord injury (SCI) model.

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BP0203-100mg	100mg	Sign in	Sign in
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Related diseases

Hyperglycemia Alzheimer's Disease Non-alcoholic fatty liver disease Melanoma Spinal Cord Injury

Related targets

Hyperglycemia PTPN1 BACE1 AMPK PTGES HSD11B1 NR1H4 NOS2 GSK3B SREBF1 NFKB1

Alzheimer's Disease PTPN1 BACE1 AMPK CASP1 TNF NOS2 GSK3B ACHE PTGS2 NFKB1 CASP3 NLRP3 BAX

Non-alcoholic fatty liver disease PTPN1 AMPK CASP1 NR1H4 TNF NOS2 ACHE SREBF1 PTGS2 NFKB1 CASP3 NLRP3 PPARA

Melanoma AMPK MMP2 TNF NOS2 PTGS2 NFKB1 CASP3 VEGFA BAX CDKN1A

Spinal Cord Injury TNF NOS2 ACHE PTGS2 NFKB1 CASP3 NLRP3 BAX

Product description Related Products Prediction Parameters Reference Literature

Product name: Asiatic acid
Synonym name: Dammarolic acid
Catalogue No.: BP0203
Cas No.: 464-92-6
Formula: C₃₀H₄₈O₅
Mol Weight: 488.709
Botanical Source: Dipterocarpus pilosus, Dryobalanops aromatica and others
Physical Description: Powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Asiatic acid is a pentacyclic triterpene contained in medicinal plants, can be used as an agent for increasing sensitivity of colon cancer cells to treatment with CPT-11 or as an agent for reducing adverse effects of CPT-11.[1]
Asiatic acid has been reported to induce apoptosis of various human cancer cells, it may exert anti-tumorigenesis through inhibitory actions in NO and COX-2 signals.[2]
Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation, its potential usage in the treatment of inflammatory bowel disease.[3]
Asiatic acid shows antidiabetic and antihyperlipidemic activity in diabetic rats.[4]
Asiatic acid (AA) has anti-inflammatory and antioxidant effects, it inhibits LPS-induced ALI in mice by inhibiting inflammatory cytokine production, which is mediated via blocking of the TLR4/NF-kB signaling pathway.[5]
Asiatic acid can inhibit cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.[6]

References:
[1] Bunpo P, Kataoka K, Arimochi H, et al. J Med Invest, 2005, 52(1-2):65-73.
[2]Park B C, Paek S H, Lee Y S, et al. Biol Pharm Bul, 2007, 30(1):176-9.
[3] Guo W, Liu W, Jin B, et al. Int Immunopharmacol, 2015, 24(2):232-8.
[4] Ramachandran V, Saravanan R, Senthilraja P. Phytomed IntJ Phytothery Phytopharmacol, 2014, 21(3):225-32.
[5] Zhiling Li, Xianzhong Xiao, Mingshi Yang. Inflammation, 2016:1-7.
[6] Zhang J, Ai L, Lv T, et al. Oncol Lett, 2013, 6(6):1762-6.
[7] Tiwari R K, Chanda S, Deepak M, et al. J Chem Pharm Res, 2010(3):223-9.