Deguelin

Name: Deguelin
Brand: Phytounique
Rating: 5 (1 reviews)

Catalogue No.： BP3110

CAS NO.: 522-17-8

Purity: 98%

Brand: Phytounique

Botanical Source: Derris trifoliata

Deguelin, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin is a potent in vitro inhibitor of the mutant form of NPM1, which provides the molecular basis for its anti-leukemia activities in NPM1 mutant acute myeloid leukemia cells.Deguelin has anti-cancer activity, such as anti osteosarcoma, lung cancer; via inducing the apoptosis of cancer cells through a ROS driven Akt pathway, EPC suppression by FAK-integrin-ILK-dependent actin remodeling .Deguelin possesses antitumor effect by targeting Akt in dual axis such as EGFR and IGF1R signaling pathways and suggests that it provides an applicable therapeutic strategy for HNSCC patients. Deguelin is a rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.

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Catalog No	Package	Original Price	Price
BP3110-20mg	20mg	Sign in	Sign in
BP3110-100mg	100mg	Sign in	Sign in
BP3110-1000mg	1000mg	Sign in	Sign in

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Related diseases

Antiparasitic Colorectal Cancer Non-small cell lung cancer Chronic Myeloid Leukemia Head and Neck Squamous Cell Carcinoma

Related targets

Antiparasitic GABAAR GLRA UNC49 AVR14 GLC1

Colorectal Cancer BCL2 HIF1A RELA PIK3CA EGFR PTGS2 AKT1 MAP2K1 CASP3 CTNNB1 CCND1 MTOR

Non-small cell lung cancer BCL2 HIF1A RELA PIK3CA BCL2L1 EGFR PTGS2 AKT1 MAP2K1 CASP3 CTNNB1 CCND1 MTOR HSP90AA1

Chronic Myeloid Leukemia BCL2 PIK3CA BCL2L1 AKT1 MTOR BCR-ABL STAT5 HSP90AA1

Head and Neck Squamous Cell Carcinoma EGFR

Product description Related Products Prediction Parameters Reference Literature

Product name: Deguelin
Synonym name:
Catalogue No.: BP3110
Cas No.: 522-17-8
Formula: C₂₃H₂₂O₆
Mol Weight: 394.423
Botanical Source:
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.