+86-28-82633987
Synonym name: Tenacissimoside C
Catalogue No.: BP1372
Cas No.: 191729-45-0
Formula: C42H66O14
Mol Weight: 794.976
Botanical Source: Marsdenia tenacissima
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
178.0400
3.3084
3.3081
.0162
.5850
2.9032
Low
67.2558
6.8281
No
No
Yes
No
No
No
0.0
Yes
No
No
No
Tenacissoside H is a natural compound isolated from the traditional Chinese medicine Marsdenia tenacissima, belonging to the Tenacissoside compound. As a traditional Chinese medicinal herb, Tongguan vine has long been widely used as an adjunct treatment against tumors and inflammation. In recent years, with the deepening of natural product pharmacology, Tamperin Tengin H has become a research hotspot due to its remarkable antitumor and anti-fibrotic activity. This compound not only exhibits good bioactivity, but also possesses superior safety and drug potential, showing promising application prospects in anti-tumor and anti-fibrotic disease treatments.
This paper will systematically review the chemical structure and physicochemical properties of Tamguan Tengin H, plant origin and extraction methods, pharmacological activity and mechanism of action, druggability evaluation, and pharmacokinetic characteristics. Finally, it explores its clinical application potential and future research directions, aiming to provide comprehensive and authoritative reference materials for researchers in related fields.
The molecular formula of Quarantine H is C_42H_66O_15, with a molecular weight of 794.9760. Its structure belongs to the macrocyclic saponin class, featuring a typical steroid saponin backbone that connects multiple glycosyl residues. The compound has a LogP value of 3.3084, indicating moderate lipid solubility, which is beneficial for cell membrane penetration. The polar surface area (TPSA) is 178.04 Ų, suggesting that the molecule has strong polar groups, which may affect its absorption and distribution characteristics.
Its low water solubility (0.0162 mg/mL) somewhat limits its oral bioavailability, but it also provides room for improvement in formulation design. Tampergin H, which does not inhibit hERG channels, indicates a low risk of cardiotoxicity. The Ames test result was 0.0, indicating no obvious mutagenicity and relatively high safety. The blood-brain barrier has a lower penetration capacity, which may limit its direct effects on central nervous system diseases but also reduces the risk of CNS side effects.
In the chemical structure of Clearguan Tengin H, the binding of steroid cores to glycosyls gives it multi-target regulatory potential, making it suitable for treating complex diseases such as tumors and fibrosis.
Tenacissima (Tenacissima) mainly comes from Marsdenia tenacissima, a perennial climbing herbaceous plant widely distributed in southern China and Southeast Asia. In traditional Chinese medicine, Tongguan vine is used as a medicinal herb for detoxifying and reducing swelling, promoting blood circulation and removing blood stasis, and anti-tumor properties.
The process for extracting Clearance Tengsin H typically includes the following steps:
In recent years, the introduction of ultrasound-assisted extraction and microwave-assisted extraction technologies has significantly improved extraction efficiency and purity, providing technical support for large-scale preparation.
Taguan Tengin H, as an important component of Taguan Tengin saponins, has demonstrated significant antitumor activity. In vitro cell experiments have shown that triguant glycoside H can inhibit the proliferation of various tumor cell lines, including lung cancer, liver cancer, gastric cancer, and breast cancer cells. Its mechanism of action involves inducing apoptosis, blocking the cell cycle, and inhibiting tumor cell migration and invasion.
In vivo experiments, Tampersine H significantly inhibited tumor growth in mouse tumor models, with minimal toxic side effects, and demonstrated a good therapeutic index. In addition, Tysin Glycoside can enhance the efficacy of chemotherapy drugs and reduce chemotherapy-related toxic side effects, offering potential adjunctive therapeutic value.
Fibrosis is a pathological process regulated by various cytokines and signaling pathways, leading to the destruction of tissue structure and function. Research on the anti-fibrosis effect of Tuantengin H has gradually increased, mainly focusing on disease models such as pulmonary fibrosis, liver fibrosis, and myocardial fibrosis.
Studies have shown that Tamguan Tengin H can significantly downregulate the expression of fibrosis-related genes, including matrix metalloproteinase MMP2, transforming growth factor β1 (TGFB1), α smooth muscle actin (ACTA2), type I collagen (COL1A1), and tissue inhibitor TIMP1, thereby inhibiting the activation and collagen deposition of fibroblasts and slowing fibrosis progression.
The multi-target mechanism of Taguan Tengin H is an important basis for its pharmacological activity. Its main targets and mechanisms include:
MMP2 (matrix metalloproteinase 2)
MMP2 plays a key role in extracellular matrix degradation and tissue remodeling. Glucosin H, by regulating MMP2 expression and activity, promotes the remodeling and balance of fibrous tissue, preventing excessive fibrosis.
TGFB1 (Transforming Growth Factor β1)
TGFB1 is a core regulator of fibrotic signaling pathways, promoting fibroblast proliferation and collagen synthesis. Mettosine H can inhibit TGFB1 signaling, blocking the initiation and progression of fibrosis.
ACTA2 (α smooth muscle actin)
ACTA2 is a biomarker of activated fibroblasts and participates in cytoskeleton remodeling and contraction functions. Tamantengin H reduces ACTA2 expression, inhibits the activation of fibroblasts, and slows the formation of fibrous tissue.
COL1A1 (Type I collagen)
COL1A1 is the main type of collagen in fibrotic tissues, and overexpression leads to tissue sclerosis. Taminosin H inhibits COL1A1 synthesis, reducing collagen deposition.
TIMP1 (matrix metalloproteinase tissue inhibitor factor 1)
TIMP1 regulates MMP activity and maintains matrix metabolic balance. Tamguan Tengin H regulates TIMP1 expression, promoting the dynamic balance between matrix degradation and synthesis.
Additionally, Clearance Tengsin H may exert comprehensive anti-tumor and anti-fibrotic effects by regulating apoptosis-related proteins (such as the Bcl-2 family), inflammatory factors (such as the NF-κB signaling pathway), and oxidative stress responses.
The druggability evaluation of Tamangtosin H indicates that it has certain development potential:
In terms of pharmacokinetics, current research is relatively limited. Preliminary in vivo experiments show that Teguan Tengin H is slowly absorbed orally, has a moderate plasma half-life, and is mainly metabolized by the liver, with excretion routes including bile and urine. In the future, further systematic studies are needed on its absorption, distribution, metabolism, and excretion (ADME) characteristics to guide clinical dosing protocol design.
As a natural product, Taoguan Tengin H, with its multi-target and multi-mechanism anti-tumor and anti-fibrotic activities, shows broad clinical application prospects. Its potential in adjuvant therapy for tumors is particularly prominent, as it can enhance the efficacy of existing chemotherapy regimens, reduce side effects, and improve patients' quality of life.
In the field of anti-fibrosis, Tamguan Tengin H offers new treatment approaches for refractory diseases such as pulmonary and liver fibrosis. By regulating key fibrosis targets, Tampertin H-clearance is expected to become an important candidate for anti-fibrotic drug development.
Future research directions should focus on:
In addition, combining modern drug design technologies, such as structural modification and nanocarrier delivery, is expected to further enhance the efficacy and druggability of trans-tasir H.
Taoguan Tengin H, as an important active ingredient in Taoguan vine, has become a research hotspot in the field of natural product pharmacology due to its unique chemical structure and multi-target pharmacological activity. Its potential applications in anti-tumor and anti-fibrotic diseases highlight the important value of natural products in modern drug development. Although research on its pharmacokinetics and clinical applications is still in its early stages, with deeper research and technological advancements, Tampersine H, as it advances, is expected to become a new generation of safe and effective treatments, bringing new hope for the treatment of related diseases. In the future, interdisciplinary collaboration should be strengthened to promote the transition of tamami glycoside H from the laboratory to clinical practice, realizing its clinical translational value.
Shenshuai
Wenjing
Hedandan
