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Product name: Tectoridin
Synonym name: Tectorigenin 7-glucoside; Shekanin; Shekkanin
Catalogue No.: BP1368
Cas No.: 611-40-5
Formula: C22H22O11
Mol Weight: 462.407
Botanical Source: Belamcanda chinensis （L.）DC.
Physical Description:
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
HPLC of Tectoridin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
179.2800
.0294
.0019
1.0867
.5680
.3949
Low
80.1681
3.9462
Yes
No
No
No
Yes
No
1.2
Yes
No
Yes
No
Tectoridin, also known as iris glycoside, is a typical isoflavone natural product, originally isolated from the leguminous plant Maackia amurensis. As a type of phytoestrogen, actinoside has attracted widespread attention in the field of natural product pharmacology in recent years due to its unique biological activity and multi-target regulatory effects. Isocarbonine not only activates the classic estrogen receptor (ER) pathway, but also mediates non-genomic signaling via the G protein-coupled receptor GPR30, demonstrating a complex regulatory network. Moreover, azimucoside shows potential therapeutic value in various pharmacological effects such as anti-inflammatory, antioxidant, and antitumor effects, especially showing remarkable activity in interventions related to inflammation-related diseases.
This paper will systematically review the chemical structure and physicochemical properties of azidine, plant origin, and extraction methods, focusing on analyzing its pharmacological activity and mechanism of action, evaluating its druggability parameters and pharmacokinetic characteristics, and finally exploring its clinical application prospects and future research directions, aiming to provide theoretical basis and scientific reference for the drug development and clinical translation of azidine.
The molecular formula of chemanoside is C22H22O11, with a molecular weight of 462.4070. Its chemical structure belongs to the isoflavone glycoside class, specifically where the isoflavone backbone is connected to the glucoside part by glycosidic bonds. The structure contains multiple hydroxyl and methoxy groups, giving it high polarity and water solubility. According to physicochemical parameters, the LogP value of azimarin is 0.0294, indicating strong hydrophilicity. The TPSA (topological pole surface area) reaches 179.2800, further supporting its good water solubility (solubility about 1.0867 mg/mL). These properties suggest that the absorption of azidoside in the body may be limited by membrane permeability, but its hydrophilicity benefits its distribution in the blood.
Azimarin has good chemical stability, is not prone to spontaneous degradation, and does not have hERG channel inhibitory activity, thereby reducing the risk of cardiotoxicity. Ames mutagenicity test results showed low mutagenicity (about 1.2), indicating high safety. The low permeability of the blood-brain barrier in abrasin, indicating its limited distribution in the central nervous system, may reduce central side effects.
Aziduside was originally isolated from the leguminous plant Maackia amurensis, which is widely distributed in Northeast Asia, especially in Northeast China and the Russian Far East. Maackia amurensis is rich in isoflavones, with spracloside, one of its main components, commonly used in medicine and research.
Common methods for extracting chetisides include solvent extraction, column chromatography separation, and high-performance liquid chromatography (HPLC) purification. Generally, ethanol or methanol is used as extraction solvents, combined with ultrasound-assisted extraction technology to improve extraction efficiency. After concentration, separation, and purification, the extract is separated by silica gel column chromatography or reversed-phase C18 column, and finally purity is determined by HPLC. In recent years, supercritical CO2 extraction and membrane separation technologies have also been attempted to extract prajoids, aiming to achieve green and efficient industrial production.
Actinoside demonstrates significant anti-inflammatory activity across various inflammation models. Its main mechanisms include inhibiting the expression of pro-inflammatory cytokines such as IL-6 and TNF-α, and regulating key molecules STAT3 and NFKB1 in inflammatory signaling pathways, thereby reducing inflammatory responses. Prajnaline can also inhibit the inflammatory mediator synthases PTGS1 (COX-1) and PTGS2 (COX-2), reducing prostaglandin production and alleviating inflammatory symptoms. Additionally, chemoside-related radiosin regulate the inflammation-related ion channels TRPV1 and TRPA1, affecting inflammation perception and pain transmission.
Radiosides, by regulating NOS2 (induced nitric oxide synthase) expression, reduces oxidative stress-mediated cell damage. Its antioxidant activity helps protect tissues from free radical damage and delays degenerative changes in inflammation-related tissues.
As a phytoestrogen, actinocylin can activate estrogen receptors ERα and ERβ, regulate the expression of estrogen-dependent genes, and exert estrogen-like biological effects. At the same time, phytoside can activate thyroid hormone receptors, affecting metabolism and growth and development. Through non-genomic pathways, cheminiglycosides activate the GPR30 receptor, rapidly regulating cell signal transduction and controlling cell proliferation, apoptosis, and metabolism.
Some studies show that actinoside has antitumor potential, can inhibit tumor cell proliferation and induce apoptosis, but the related mechanisms still require further exploration. In addition, it also shows certain activity in immune regulation and neuroprotection, suggesting its potential application in multisystem diseases.
The biological activity of cheminithin depends on its multi-target and multi-pathway regulatory mechanisms. Its main mechanisms of action include:
ER-dependent genomic pathway
As a plant estrogen, radiosinoside binds to the estrogen receptors ERα and ERβ in the cell nucleus, inducing receptor conformational changes, promoting binding of receptors to estrogen response elements on DNA, and regulating the transcriptional expression of target genes. This pathway affects the expression of genes related to cell cycle regulation, metabolic regulation, and inflammatory responses.
GPR30-dependent non-genomic pathway
Inocheside activates the GPR30 receptor on the membrane surface, rapidly initiating intracellular signal transduction pathways such as cAMP, PI3K/Akt, and MAPK, regulating cell proliferation, apoptosis, and metabolic activities. This non-genomic mechanism enables aquatic glycosides to quickly respond to changes in the cellular environment and exert diverse biological effects.
Regulation of anti-inflammatory signaling pathways
Arcanoids inhibit the NFKB1 signaling pathway, reduce the expression of pro-inflammatory factors such as TNF-α and IL-6, lower STAT3 activation, and thereby suppress the inflammatory cascade. The regulatory effect of CASP1 reduces the release of inflammatory mediators and alleviates tissue damage.
Ion channel regulation
Radioside's regulation of TRPV1 and TRPA1 channels affects the transmission of pain and inflammatory signals, providing both analgesic and anti-inflammatory effects.
The druggability parameters of spinoside indicate that it has certain potential for drug development. It has a moderate molecular weight and good water solubility, which is beneficial for the development of oral formulations. Low LogP values and high TPSA suggest low cell membrane permeability, which may limit oral absorption but simultaneously reduce nonspecific lipophilic toxicity.
Low blood-brain barrier penetration reduces the risk of central nervous system side effects. No inhibitory activity of hERG channels, reducing the possibility of cardiotoxicity. Ames test results show that it has low mutagenicity and good safety.
Pharmacokinetics, existing studies show that azidine is metabolized stably in the body, mainly transformed through the hepatic metabolic enzyme system, with most metabolites being deglycosylated isoflavone active components. Prisolate has a moderate half-life and a high plasma protein binding rate, suggesting its wide distribution in the body, but its specific absorption, distribution, metabolism, and excretion (ADME) characteristics still require further systematic study.
As a versatile plant estrogen, actinoside has broad clinical application potential. Its significant anti-inflammatory effect gives it potential therapeutic value in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and skin inflammation. By regulating estrogen and thyroid hormone receptors, radioshanoids may have a positive impact on hormone-related diseases such as menopausal syndrome, osteoporosis, and metabolic syndrome.
Moreover, the antioxidant and cell-protective effects of azidoside offer potential for adjunctive treatment of neurodegenerative and cardiovascular diseases. Its low toxicity and good safety lay the foundation for long-term use.
Future research should focus on optimizing the pharmacokinetics, developing formulations, and verifying clinical efficacy of cheminidine. Combining modern drug delivery systems, such as nanocarriers and targeted formulations, is expected to improve bioavailability and therapeutic efficacy. At the same time, in-depth analysis of its molecular mechanisms, especially its interactions with inflammatory and hormonal signaling pathways, will provide scientific evidence for precision treatment strategies for bratoside.
As a natural isoflavone with a clear origin and unique structure, it demonstrates broad pharmacological activity and good druggability due to its ability to activate estrogen and thyroid hormone receptors and its multi-target anti-inflammatory effects. Its potential in anti-inflammation, hormone regulation, and cell protection provides valuable resources for the development of novel natural medicines. Although current research on chetisides is still in the basic and preliminary application stages, its good safety and versatility suggest broad clinical application prospects. In the future, through systematic pharmacological mechanism analysis and clinical research, RSIG is expected to become an important candidate molecule for the development of natural product drugs, bringing new hope for the treatment of related diseases.
Shenshuai
Wenjing
Hedandan
