+86-28-82633987
Product name: Sinensetin
Synonym name: 3′,4′,5,6,7-Pentamethoxyflavone
Catalogue No.: BP1310
Cas No.: 2306-27-6
Formula: C20H20O7
Mol Weight: 372.373
Botanical Source: Found in orange peel and other plant sources such as Orthosiphon spicatus
Physical Description: Yellow powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activity.[1]
Sinensetin has antioxidative effect and has anti-inflammatory by regulating the protein level of inhibitorκB-α, which may be utilized in the development of novel anti-inflammatory treatments.[2-4]
Sinensetin enhances activation of protein kinase A and increases intracellular cAMP levels in 3T3-L1 preadipocytes, it stimulates lipolysis via a cAMP pathway in mature 3T3-L1 adipocytes, suggests that sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes.[5]
References:
[1] Lam I K, Alex D, You-Hua Wang ?, et al. Mol Nut Food Res, 2012, 56(6):945–56.
[2] M. Amzad Hossain, S.M. Salehuddin, M.J. Kabir, et al. Food Chem 2009, 113(1):185-90.
[3] Laavola M, Nieminen R, Yam M F, et al. Planta Med, 2012, 78(8):779-86.
[4] Shin H S, Kang S I, Yoon S A, et al. Biosci Biotech Biochem, 2012, 76(4):847-9.
[5] Kang S I, Shin H S, Kim S J. Biol Pharm Bull, 2015, 38(4):552-8.
[6] Mun F Y, Elsnoussi Ali Hussin Mohamed, Lee Fung Ang,et al. J Acupuncture & Meridian Studies, 2012, 5(4):176-82.
HPLC of Sinensetin
HNMR of Sinensetin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
76.3600
2.8520
2.8520
.0024
2.9111
33.3948
High
87.1058
2.2378
Yes
No
Yes
No
Yes
No
0.9
No
No
No
Yes
Shenshuai
Wenjing
Hedandan
