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Product name: Sennidin A
Synonym name:
Catalogue No.: BP1290
Cas No.: 641-12-3
Formula: C30H18O10
Mol Weight: 538.464
Botanical Source: Aglycone from Sennoside A
Physical Description: Yellow powder
Type of Compound: Anthraquinones
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Sennidin A in combination with necrosis inducing drugs/therapies may generate synergetic tumoricidal effects on solid malignancies by means of primary debulking and secondary cleansing process.[1]
Sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent in rat adipocytes, but in the IR/IRS1-independent manner.[2]
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 uM.[3]
References:
[1] Ji Y, Jiang C, Zhang X, et al. Oncotarget, 2014, 5(10):2934-46.
[2] Abe D, Saito T, Sekiya K. Life Sci, 2006, 79(11):1027-33.
[3] Furuta A, Tsubuki M, Endoh M, et al. Int J Mol Sci, 2014, 16(8):18439-53.
[4] Sun Y, Li XT, Yu XG,et al. Chinese Journal of Chromatography, 2004, 22(1):48-50.
HPLC of Sennidin A
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
189.6600
3.6773
.5656
.0370
3.9375
1.8957
Low
92.4107
3.6474
Yes
No
No
No
Yes
Yes
0.0
Yes
No
Yes
No
Shenshuai
Wenjing
Hedandan
