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Synonym name: Sedanenolide; 3-Butyl-4,5-dihydrophthalide; Senkyunolide
Catalogue No.: BP1287
Cas No.: 63038-10-8
Formula: C12H16O2
Mol Weight: 192.258
Botanical Source: dried rhizome of Cnidium officinale, the crude drug senkyu and Apium graveolens (celery)
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Description:
Reference standards.
References:
Chinese Journal of Pharmaceutical Analysis, 2012, 32(9):1644-1647.
HPLC determination of equilibrium solubility and apparent oil/water partition coefficient of senkyunolide.
To determine the equilibrium solubility of senkyunoide and its partition coefficients for the n-octanol-water/buffer solution systems,so as to provide a basis for new formulations designing.
METHODS AND RESULTS:
A high performance liquid chromatography method was established to detect the concentration of Senkyunolide .The Megres ODS(5 μm,4.6 mm×100 mm)column was adopted,the mobile phase was acetonitrile-water(1:3, v/v)at a flow rate of 1.0 mL·min-1,and the detection wavelength was 278 nm.The concentration of Senkyunolide in different pH solutions and the partition coefficients for the n-octanol-water and n-octanol-buffer solution systems were detected. The equilibrium solubility reached a maximum of 34.31 mg·mL-1in water at 37°C.Senk yunolide was instable in solvent systems pH≥9.0.Partition coefficient of Senkyunolidewas 13.43(lg P app=1.13) in the n-octanol-water system;there was no significant effect of pH to partition coefficient of Senkyunolide .
CONCLUSIONS:
The study showed that Senkyunolide is soluble,the partition coefficient of Senkyunolide is moderate,and the relative molecular mass of Senkyunolide is small.Therefore,we can explain why Senkyunolide can quickly reach into blood and brain.Senkyunolide can be predicted with a good application value.
HPLC of Senkyunolide A
HNMR of Senkyunolide A
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
26.3000
3.4456
3.4456
.1342
6.6419
7.5580
High
84.1801
3.6767
No
Yes
No
No
No
Yes
0.0
No
Yes
Yes
Yes
Shenshuai
Wenjing
Hedandan
