Rotenone

Name: Rotenone
Brand: Phytopurify
Rating: 5 (1 reviews)

Catalogue No.： BP3347

CAS NO.: 83-79-4

Purity: 98%

Brand: Phytopurify

Botanical Source: Derris trifoliata

Rotenone is a mitochondrial complex I inhibitor that produces an animal model of Parkinson's disease. Rotenone-induced α-synuclein aggregation is mediated by the calcium/GSK3β signaling pathway. Rotenone can increase intracellular levels of the toxic dopamine metabolite 3,4-dihydroxyphenyl-acetaldehyde (DOPAL), via decreasing DOPAL metabolism by aldehyde dehydrogenase (ALDH) and decreasing vesicular sequestration of cytoplasmic dopamine by the vesicular monoamine transporter (VMAT). Rotenone is a member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).

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BP3347-100mg	100mg	Sign in	Sign in
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Contacts：400-829-7929，028-82633860，82633397，82633165

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Related diseases

Parkinson's Disease Liver fibrosis Antitumor Neurodegenerative Diseases (Alzheimer's Disease) Inflammatory Diseases (e.g., Sepsis-related Inflammation)

Related targets

Parkinson's Disease APP BCL2 MAPT CASP1 RELA TNF GSK3B CASP3 SNCA IL1B NLRP3 BAX PINK1

Liver fibrosis BCL2 CASP1 RELA TNF CASP3 IL1B TGFB1 ACTA2 BAX

Antitumor BCL2 TP53 CASP3 MYC BAX CDKN1A

Neurodegenerative Diseases (Alzheimer's Disease) APP MAPT RELA TNF GSK3B IL1B NLRP3 PSEN1

Inflammatory Diseases (e.g., Sepsis-related Inflammation) CASP1 RELA TNF IL1B NLRP3

Product description Related Products Prediction Parameters Reference Literature

Product name: Rotenone
Synonym name:
Catalogue No.: BP3347
Cas No.: 83-79-4
Formula: C₂₃H₂₂O₆
Mol Weight: 394.423
Botanical Source:
Physical Description: Cryst.
Type of Compound: Miscellaneous

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.